SPECTINOMYCIN MODIFICATION. III: CHLORO-DEOXY ANALOGS

SPECTINOMYCIN MODIFICATION. III: CHLORO-DEOXY ANALOGS

9-Epichloro-9-deoxy-4(R)-dihydrospectinomycin (3), 9-chloro-9-deoxy-4(R)-dihydrospectinomycin (7), 9-deoxy-8, 9-epimino-4(R)-dihydrospectinomycin (6), and 9-epichloro-9-deoxyspectinomycin (10) have been prepared and their structures established by proton magnetic resonance. These analogs are devoid...

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Veröffentlicht in:Journal of antibiotics 1977, Vol.30(11), pp.960-964
Hauptverfasser: CARNEY, RONALD E., ROSENBROOK, WILLIAM, Jr
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria - drug effects
Chemical Phenomena
Chemistry
Spectinomycin - analogs & derivatives
Spectinomycin - pharmacology
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Zusammenfassung:9-Epichloro-9-deoxy-4(R)-dihydrospectinomycin (3), 9-chloro-9-deoxy-4(R)-dihydrospectinomycin (7), 9-deoxy-8, 9-epimino-4(R)-dihydrospectinomycin (6), and 9-epichloro-9-deoxyspectinomycin (10) have been prepared and their structures established by proton magnetic resonance. These analogs are devoid of antibiotic activity.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.30.960