Alcohol sensitivity in female mice: Effect of ovariectomy

Alcohol sensitivity in female mice: Effect of ovariectomy

This study tested the hypothesis that decreased estrogen levels accomplished by removing the ovaries affect the response to acutely administered alcohol in female mice. Sensitivity to alcohol was measured in ovariectomized, sham-operated, and non-surgical control C3H/HEN mice. Each animal received a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1981-08, Vol.15 (2), p.191-195
Hauptverfasser: Randall, Carrie L., Lochry, Elizabeth A., Moseley, James W., Sutker, Patricia B.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol
Alcohol sensitivity
Animals
Body Temperature - drug effects
Body Weight - drug effects
C3H mice
Castration
Core temperature
Estrogen
Estrous cycle
Estrus
Ethanol - pharmacology
Female
Mice
Mice, Inbred C3H
Ovariectomy
Pregnancy
Sleep - drug effects
Sleeptime
Time Factors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This study tested the hypothesis that decreased estrogen levels accomplished by removing the ovaries affect the response to acutely administered alcohol in female mice. Sensitivity to alcohol was measured in ovariectomized, sham-operated, and non-surgical control C3H/HEN mice. Each animal received an IP injection of alcohol (3.0 or 4.0 g/kg). Core temperature, fall time, sleeptime, and waking blood alcohol levels were the dependent variables. For each of these measures, alcohol sensitivity was found to be a function of the dose of alcohol administered, but not the surgical condition. Additionally, the stage of estrus in control animals was not found to be related to alcohol sensitivity.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(81)90176-3