Human Antibody Genes: V Gene Variability and CH Gene Switching Strategies
In this review article the authors have aummarized experimental results obtained with isolated human antibody genes. Firstly the authors discuss details of the structure and multiplicity of germline Vk genes in relation to possible somatic mutation of these V segments. the authors discuss data on C...
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| Veröffentlicht in: | Immunological reviews 1981-01, Vol.59 (1), p.69-91 |
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| container_title | Immunological reviews |
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| creator | Rabbitts, T. H. Bentley, D. L. Milstein, Celia P. |
| description | In this review article the authors have aummarized experimental results obtained with isolated human antibody genes. Firstly the authors discuss details of the structure and multiplicity of germline Vk genes in relation to possible somatic mutation of these V segments. the authors discuss data on C mu , C delta and C gamma genes relevant to the mechanism by which these various CH genes can share single VH gene sequence. |
| doi_str_mv | 10.1111/j.1600-065X.1981.tb00456.x |
| format | Article |
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L.</creatorcontrib><creatorcontrib>Milstein, Celia P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunological reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rabbitts, T. H.</au><au>Bentley, D. L.</au><au>Milstein, Celia P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Antibody Genes: V Gene Variability and CH Gene Switching Strategies</atitle><jtitle>Immunological reviews</jtitle><addtitle>Immunol Rev</addtitle><date>1981-01-01</date><risdate>1981</risdate><volume>59</volume><issue>1</issue><spage>69</spage><epage>91</epage><pages>69-91</pages><issn>0105-2896</issn><eissn>1600-065X</eissn><abstract>In this review article the authors have aummarized experimental results obtained with isolated human antibody genes. 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| fulltext | fulltext |
| identifier | ISSN: 0105-2896 |
| ispartof | Immunological reviews, 1981-01, Vol.59 (1), p.69-91 |
| issn | 0105-2896 1600-065X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73753297 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amino Acid Sequence Animals Antibodies - genetics Base Sequence Biological Evolution Cloning, Molecular DNA Restriction Enzymes DNA, Recombinant - immunology Genes Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin kappa-Chains - genetics Mice Nucleic Acid Hybridization |
| title | Human Antibody Genes: V Gene Variability and CH Gene Switching Strategies |
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