Human Antibody Genes: V Gene Variability and CH Gene Switching Strategies

Human Antibody Genes: V Gene Variability and CH Gene Switching Strategies

In this review article the authors have aummarized experimental results obtained with isolated human antibody genes. Firstly the authors discuss details of the structure and multiplicity of germline Vk genes in relation to possible somatic mutation of these V segments. the authors discuss data on C...

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Veröffentlicht in:Immunological reviews 1981-01, Vol.59 (1), p.69-91
Hauptverfasser: Rabbitts, T. H., Bentley, D. L., Milstein, Celia P.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Antibodies - genetics
Base Sequence
Biological Evolution
Cloning, Molecular
DNA Restriction Enzymes
DNA, Recombinant - immunology
Genes
Humans
Immunoglobulin Heavy Chains - genetics
Immunoglobulin kappa-Chains - genetics
Mice
Nucleic Acid Hybridization
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Beschreibung
Zusammenfassung:In this review article the authors have aummarized experimental results obtained with isolated human antibody genes. Firstly the authors discuss details of the structure and multiplicity of germline Vk genes in relation to possible somatic mutation of these V segments. the authors discuss data on C mu , C delta and C gamma genes relevant to the mechanism by which these various CH genes can share single VH gene sequence.
ISSN:0105-2896
1600-065X
DOI:10.1111/j.1600-065X.1981.tb00456.x