Steroid hormones increase the growth of MuLV in rat tumor XC cells

Steroid hormones increase the growth of MuLV in rat tumor XC cells

Ecotropic MuLV, which do not normally grow efficiently in XC cells, were found to do so under the influence of specific steroid hormones. The adsorption of virus to the cells was not facilitated by the steroids. The increase in MuLV production by XC cells involves an increased viral progeny output p...

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Veröffentlicht in:Virology (New York, N.Y.) N.Y.), 1977-12, Vol.83 (2), p.462-466
Hauptverfasser: Gautsch, James W., Bedigian, Hendrick G., Meier, Hans
Format: Artikel
Sprache:eng
Schlagworte:
Adrenal Cortex Hormones - pharmacology
Androgens - pharmacology
Cell Fusion - drug effects
Cell Line
Dexamethasone - pharmacology
Estrogens - pharmacology
Moloney murine leukemia virus - growth & development
Time Factors
Viral Plaque Assay
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Zusammenfassung:Ecotropic MuLV, which do not normally grow efficiently in XC cells, were found to do so under the influence of specific steroid hormones. The adsorption of virus to the cells was not facilitated by the steroids. The increase in MuLV production by XC cells involves an increased viral progeny output per cell, thereby defining an intracellular restriction by rat cells on ecotropic MuLV growth. Cell lines other than the XC were not similarly stimulated. The steroid-induced increase in MuLV growth is accompanied by enhanced XC cell fusion.
ISSN:0042-6822
1096-0341
DOI:10.1016/0042-6822(77)90196-9