Copper in Cadmium-exposed Rat Kidney Metallothionein

Copper in Cadmium-exposed Rat Kidney Metallothionein

In vitro affinity of cupric ion to metallothionein was found to be stronger than cadmium and zinc ions. The result suggested the passive incorporation of copper into the metallothionein and the possibility of demasking of the masked cadmium toxicity as metallothionein. Copper contents of cadmium-exp...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1977/10/25, Vol.25(10), pp.2792-2794
Hauptverfasser: SUZUKI, KAZUO T., KUBOTA, KENTARO, TAKENAKA, SHINJI
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cadmium - pharmacology
Copper - metabolism
Kidney - drug effects
Kidney - metabolism
Metalloproteins - metabolism
Metallothionein - metabolism
Rats
zinc
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Zusammenfassung:In vitro affinity of cupric ion to metallothionein was found to be stronger than cadmium and zinc ions. The result suggested the passive incorporation of copper into the metallothionein and the possibility of demasking of the masked cadmium toxicity as metallothionein. Copper contents of cadmium-exposed rat kidney metallothionein were analyzed along with cadmium and zinc. The copper in kidney metallothionein was always one of major metals along with zinc and cadmium. On the other hand, the copper in cadmium-exposed liver metallothionein was a minor metal.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.25.2792