STUDIES ON THE IONOPHOROUS ANTIBIOTICS. XXVII: THE STRUCTURES OF TM-531B (4'-O-DEM ETHYLDIANEM YCIN) AND TM-531C(3'-HYDROXYDIANEMYCIN), NEW POLYETHER ANTIBIOTICS CONTAINING SUGARS OTHER THAN 4-O-METHYL AMICETOSE

STUDIES ON THE IONOPHOROUS ANTIBIOTICS. XXVII: THE STRUCTURES OF TM-531B (4'-O-DEM ETHYLDIANEM YCIN) AND TM-531C(3'-HYDROXYDIANEMYCIN), NEW POLYETHER ANTIBIOTICS CONTAINING SUGARS OTHER THAN 4-O-METHYL AMICETOSE

In course of a screening program for these new substances, two polyether antibiotics TM-531B and TM-531C have been isolated as their sodium salts from the fermentation broth of Streptomyces hygroscopicus TM-531, a producing organism of leuseramycin and dianemycin. Their physicochemical properties re...

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Veröffentlicht in:Journal of antibiotics 1981, Vol.34(10), pp.1369-1373
Hauptverfasser: MIZUTANI, TAKU, YAMAGISHI, MICHIO, MIZOUE, KAZUTOSHI, KAWASHIMA, AKIRA, OMURA, SADAFUMI, OZEKI, MASAHIRO, SETO, HARUO, OTAKE, NOBORU
Format: Artikel
Sprache:eng
Schlagworte:
Aminoglycosides
Anti-Bacterial Agents
Chemical Phenomena
Chemistry
Glycosides
Ionophores
Magnetic Resonance Spectroscopy
Streptomyces hygroscopicus
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Zusammenfassung:In course of a screening program for these new substances, two polyether antibiotics TM-531B and TM-531C have been isolated as their sodium salts from the fermentation broth of Streptomyces hygroscopicus TM-531, a producing organism of leuseramycin and dianemycin. Their physicochemical properties revealed that both are closely related congeners of dianemycin. This communication deals with their structural elucidation mainly based on the use of super(13)C NMR spectroscopy.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.34.1369