Modulation of concanavalin A‐induced lymphocyte stimulation by human low‐density lipoproteins

Modulation of concanavalin A‐induced lymphocyte stimulation by human low‐density lipoproteins

Spleen lymphocytes and T cells were stimulated by concanavalin A in the presence of various concentrations of human low‐density lipoproteins (LDL). The proliferative responses were measured by [14C]thymidine incorporation. Low LDL doses (5–50 μg/ml) significantly enhanced the stimulation of splenic...

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Veröffentlicht in:European journal of immunology 1981, Vol.11 (10), p.846-848
Hauptverfasser: Waelti, Ernst R., Glueck, Reinhard, Hess, Max W.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
B-Lymphocytes
Cell Separation
Concanavalin A - pharmacology
Dose-Response Relationship, Immunologic
Female
Humans
Lipoproteins, LDL - pharmacology
Lymphocyte Activation
Mice
Mice, Inbred BALB C
T-Lymphocytes
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Zusammenfassung:Spleen lymphocytes and T cells were stimulated by concanavalin A in the presence of various concentrations of human low‐density lipoproteins (LDL). The proliferative responses were measured by [14C]thymidine incorporation. Low LDL doses (5–50 μg/ml) significantly enhanced the stimulation of splenic lymphocytes and T cells. Further, LDL had the capacity to partially relieve the suppression produced by supraoptimal doses of concanavalin A.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.1830111019