β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior
Centrally administered β-endorphin or morphine suppressed fixed-ratio 15, food-reinforced responding by rats in a dose- dependent manner. β-Endorphin was 21 times more potent than morphine on a molar basis. Scratching and wet-dog shakes were observed within 30 minutes of β-endorphin administration b...
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| Veröffentlicht in: | Life sciences (1973) 1977-10, Vol.21 (7), p.927-932 |
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| container_end_page | 932 |
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| container_issue | 7 |
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| container_title | Life sciences (1973) |
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| creator | Lichtblau, Leonard Fossom, Linda H. Sparber, Sheldon B. |
| description | Centrally administered β-endorphin or morphine suppressed fixed-ratio 15, food-reinforced responding by rats in a dose- dependent manner. β-Endorphin was 21 times more potent than morphine on a molar basis. Scratching and wet-dog shakes were observed within 30 minutes of β-endorphin administration but were not seen after morphine and did not appear to be responsible for the suppression of the conditioned behavior. |
| doi_str_mv | 10.1016/0024-3205(77)90257-0 |
| format | Article |
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Scratching and wet-dog shakes were observed within 30 minutes of β-endorphin administration but were not seen after morphine and did not appear to be responsible for the suppression of the conditioned behavior.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(77)90257-0</identifier><identifier>PMID: 927021</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Conditioning, Operant - drug effects ; Dose-Response Relationship, Drug ; Endorphins - administration & dosage ; Endorphins - pharmacology ; Injections, Intraventricular ; Male ; Morphine - pharmacology ; Rats ; Reinforcement Schedule ; Time Factors</subject><ispartof>Life sciences (1973), 1977-10, Vol.21 (7), p.927-932</ispartof><rights>1977</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-25ec6944c5ad7ae64638cafec46dad6aee7b95c17bc5a10369e676a02561f51a3</citedby><cites>FETCH-LOGICAL-c356t-25ec6944c5ad7ae64638cafec46dad6aee7b95c17bc5a10369e676a02561f51a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(77)90257-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/927021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lichtblau, Leonard</creatorcontrib><creatorcontrib>Fossom, Linda H.</creatorcontrib><creatorcontrib>Sparber, Sheldon B.</creatorcontrib><title>β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Centrally administered β-endorphin or morphine suppressed fixed-ratio 15, food-reinforced responding by rats in a dose- dependent manner. β-Endorphin was 21 times more potent than morphine on a molar basis. Scratching and wet-dog shakes were observed within 30 minutes of β-endorphin administration but were not seen after morphine and did not appear to be responsible for the suppression of the conditioned behavior.</description><subject>Animals</subject><subject>Conditioning, Operant - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endorphins - administration & dosage</subject><subject>Endorphins - pharmacology</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Morphine - pharmacology</subject><subject>Rats</subject><subject>Reinforcement Schedule</subject><subject>Time Factors</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS3EqxT-oIusECwMdhzbDQskVB5FqsQG1pZjT1SjNg52UsFv8SF8Ey6tumQ10sy5V5qD0IiSK0qouCYkLzDLCb-Q8rIkOZeY7KEBHcsSE8HoPhrskGN0EuM7IYRzyY7QYZlLktMBmv58Y2isD-3cNTfZvY-ALbRpBU2Xxb5tA8TofJP5OqvdJ1gcdOd85lsIOiEVzPXK-XCKDmq9iHC2nUP09vjwOpni2cvT8-Ruhg3josM5ByPKojBcW6lBFIKNja7BFMJqKzSArEpuqKwSQQkTJQgpdHpO0JpTzYbofNPbBv_RQ-zU0kUDi4VuwPdRSSZZglkCiw1ogo8xQK3a4JY6fClK1NqfWstRazlKSvXnT5EUG237-2oJdhfaCEvn280Z0o8rB0FF46AxYF0A0ynr3f_9v2WFgCA</recordid><startdate>19771001</startdate><enddate>19771001</enddate><creator>Lichtblau, Leonard</creator><creator>Fossom, Linda H.</creator><creator>Sparber, Sheldon B.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19771001</creationdate><title>β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior</title><author>Lichtblau, Leonard ; Fossom, Linda H. ; Sparber, Sheldon B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-25ec6944c5ad7ae64638cafec46dad6aee7b95c17bc5a10369e676a02561f51a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Conditioning, Operant - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endorphins - administration & dosage</topic><topic>Endorphins - pharmacology</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Morphine - pharmacology</topic><topic>Rats</topic><topic>Reinforcement Schedule</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lichtblau, Leonard</creatorcontrib><creatorcontrib>Fossom, Linda H.</creatorcontrib><creatorcontrib>Sparber, Sheldon B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lichtblau, Leonard</au><au>Fossom, Linda H.</au><au>Sparber, Sheldon B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1977-10-01</date><risdate>1977</risdate><volume>21</volume><issue>7</issue><spage>927</spage><epage>932</epage><pages>927-932</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Centrally administered β-endorphin or morphine suppressed fixed-ratio 15, food-reinforced responding by rats in a dose- dependent manner. β-Endorphin was 21 times more potent than morphine on a molar basis. 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| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1977-10, Vol.21 (7), p.927-932 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73732563 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Conditioning, Operant - drug effects Dose-Response Relationship, Drug Endorphins - administration & dosage Endorphins - pharmacology Injections, Intraventricular Male Morphine - pharmacology Rats Reinforcement Schedule Time Factors |
| title | β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior |
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