β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior

β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior

Centrally administered β-endorphin or morphine suppressed fixed-ratio 15, food-reinforced responding by rats in a dose- dependent manner. β-Endorphin was 21 times more potent than morphine on a molar basis. Scratching and wet-dog shakes were observed within 30 minutes of β-endorphin administration b...

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Veröffentlicht in:Life sciences (1973) 1977-10, Vol.21 (7), p.927-932
Hauptverfasser: Lichtblau, Leonard, Fossom, Linda H., Sparber, Sheldon B.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Conditioning, Operant - drug effects
Dose-Response Relationship, Drug
Endorphins - administration & dosage
Endorphins - pharmacology
Injections, Intraventricular
Male
Morphine - pharmacology
Rats
Reinforcement Schedule
Time Factors
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Zusammenfassung:Centrally administered β-endorphin or morphine suppressed fixed-ratio 15, food-reinforced responding by rats in a dose- dependent manner. β-Endorphin was 21 times more potent than morphine on a molar basis. Scratching and wet-dog shakes were observed within 30 minutes of β-endorphin administration but were not seen after morphine and did not appear to be responsible for the suppression of the conditioned behavior.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(77)90257-0