Retrolental Fibroplasia: Efficacy of Vitamin E in a Double-Blind Clinical Study of Preterm Infants

We performed a double-blind study in 101 preterm infants who weighed ≤1500 g at birth, who had respiratory distress, and who survived for at least four weeks, to evaluate the efficacy of oral vitamin E in preventing the development of retrolental fibroplasia. Weekly indirect ophthalmologic examinati...

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Veröffentlicht in:	The New England journal of medicine 1981-12, Vol.305 (23), p.1365-1371
Hauptverfasser:	Hittner, Helen Mintz, Godio, Louis B, Rudolph, Arnold J, Adams, James M, Garcia-Prats, Joseph A, Friedman, Zvi, Kautz, Judith A, Monaco, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Age Anemia Babies Birth Weight Body weight Cerebral Hemorrhage - complications Clinical trials Clinical Trials as Topic Double-Blind Method Double-blind studies Drug dosages Gestational Age Hemorrhage Hospitals Humans Infant, Newborn Infants Multiple births Multivariate analysis Newborn babies Oxygen Inhalation Therapy - adverse effects Pediatrics Plasma Premature babies Respiratory Distress Syndrome, Newborn - complications Respiratory Distress Syndrome, Newborn - therapy Retinopathy of Prematurity - etiology Retinopathy of Prematurity - prevention & control Risk Risk factors Sepsis Statistical analysis Vitamin E Vitamin E - administration & dosage Vitamin E - blood Vitamin E - therapeutic use
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Zusammenfassung:	We performed a double-blind study in 101 preterm infants who weighed ≤1500 g at birth, who had respiratory distress, and who survived for at least four weeks, to evaluate the efficacy of oral vitamin E in preventing the development of retrolental fibroplasia. Weekly indirect ophthalmologic examinations begun when the infants were three weeks old revealed a significant decrease in the incidence of retrolental fibroplasia ≥ Grade III (P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198112033052301