Regional circadian variation of acetylcholine muscarinic receptors in the rat brain

The level of binding of a labeled acetylcholine muscarinic antagonist (quinuclidinyl benzilate) to different cerebral membranes has been measured. Of the regions examined, circadian rhythmicity of binding could only be detected significantly in the hippocampus and the hypothalamus and not in the cer...

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Veröffentlicht in:	J. Neurosci. Res.; (United States) 1981, Vol.6 (3), p.315-318
Hauptverfasser:	Por, Suzanne B., Bondy, Stephen C.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques 551001 - Physiological Systems- Tracer Techniques ACETYLCHOLINE AMINES AMMONIUM COMPOUNDS Animals AUTONOMIC NERVOUS SYSTEM AGENTS BASIC BIOLOGICAL SCIENCES BENZILIC ACID binding sites BIOCHEMICAL REACTION KINETICS BODY BRAIN Brain - metabolism CARBOXYLIC ACIDS CENTRAL NERVOUS SYSTEM CEREBELLUM CEREBRAL CORTEX CEREBRUM circadian Circadian Rhythm DAILY VARIATIONS DRUGS ESTERS Hippocampus - metabolism HYDROXY ACIDS HYPOTHALAMUS KINETICS Male MEDICINE MEMBRANES NERVOUS SYSTEM NEUROLOGY NEUROREGULATORS ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS PARASYMPATHOMIMETICS PHYSIOLOGY QUATERNARY COMPOUNDS Quinuclidinyl Benzilate - metabolism Rats REACTION KINETICS RECEPTORS Receptors, Cholinergic - metabolism Receptors, Muscarinic - metabolism Tritium VARIATIONS
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Beschreibung
Zusammenfassung:	The level of binding of a labeled acetylcholine muscarinic antagonist (quinuclidinyl benzilate) to different cerebral membranes has been measured. Of the regions examined, circadian rhythmicity of binding could only be detected significantly in the hippocampus and the hypothalamus and not in the cerebral cortex, striatum, or cerebellum.
ISSN:	0360-4012 1097-4547
DOI:	10.1002/jnr.490060306