Antithrombotic activity of a polydeoxyribonucleotidic substance extracted from mammalian organs: A possible link with prostacyclin

The antithrombotic activity of Fraction P (FP), a polydeoxyribonucleotide extracted from mammalian organs, was studied in different models of experimental thrombosis. FP displays a remarkable protec ting activity against thrombosis induced by collagen (venous thrombosis), electrical stimulation (arterial thrombosis) and iontophoretic application of ADP (venular thrombosis). The activity of FP is long lasting and evident either by oral administration or intra venous injection. The antithrombotic activity of FP is partly due to its already reported fibrinolytic effect, but also other mechanisms which involve vascular reactivity and platelet function may come into play. The ability of FP to promote generation and release in the circulation of a deaggregating substance and to increase prostacyclin-like activity from incubated aortic tissue is discussed in order to explain the mode of action of FP in preventing thrombosis formation.