Epileptic seizures and syndromes in twins: the importance of genetic factors

The role of genetic factors in the occurrence of epilepsy syndromes was studied in twins recruited from the population-based Danish Twin Registry. A total of 34,076 twins were screened for epilepsy. Cases were confirmed and classified by two neurologists according to the classification systems of th...

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Veröffentlicht in:	Epilepsy research 2003-06, Vol.55 (1), p.137-146
Hauptverfasser:	Kjeldsen, Marianne Juel, Corey, Linda A., Christensen, Kaare, Friis, Mogens Laue
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Chi-Square Distribution Concordance Databases, Genetic - statistics & numerical data Diseases in Twins - epidemiology Diseases in Twins - genetics Epilepsy Epilepsy - epidemiology Epilepsy - genetics Female Genetic Markers - genetics Genetics Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Heritability Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Seizures Syndrome Twins Twins, Dizygotic - genetics Twins, Dizygotic - statistics & numerical data Twins, Monozygotic - genetics Twins, Monozygotic - statistics & numerical data
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Zusammenfassung:	The role of genetic factors in the occurrence of epilepsy syndromes was studied in twins recruited from the population-based Danish Twin Registry. A total of 34,076 twins were screened for epilepsy. Cases were confirmed and classified by two neurologists according to the classification systems of the International League Against Epilepsy (ILAE). A total of 214 twin pairs with epileptic seizures and 190 pairs with epilepsy were ascertained. Significantly higher concordance rates were found for monozygotic (MZ) compared to dizygotic (DZ) twins for both epileptic seizures (0.56 for MZ and 0.21 for DZ pairs, P
ISSN:	0920-1211 1872-6844
DOI:	10.1016/S0920-1211(03)00117-7