Erythrocyte Lipids in Heterozygous Carriers of Duchenne Muscular Dystrophy
Erythrocyte membranes from heterozygous carriers of Duchenne muscular dystrophy exhibit a diminished amount of palmitoleic acid when compared to membranes from normal subjects. A similar, but more variable, diminution is observed in the case of patients with this disorder. The change in fatty acid c...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1977-10, Vol.198 (4314), p.309-310 |
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| container_issue | 4314 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Howland, John L. Iyer, Susheela L. |
| description | Erythrocyte membranes from heterozygous carriers of Duchenne muscular dystrophy exhibit a diminished amount of palmitoleic acid when compared to membranes from normal subjects. A similar, but more variable, diminution is observed in the case of patients with this disorder. The change in fatty acid composition appears related to a low membrane triglyceride content and may provide both a possible technique for carrier detection and a clue regarding pathogenesis. |
| doi_str_mv | 10.1126/science.910129 |
| format | Article |
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A similar, but more variable, diminution is observed in the case of patients with this disorder. The change in fatty acid composition appears related to a low membrane triglyceride content and may provide both a possible technique for carrier detection and a clue regarding pathogenesis.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.910129</identifier><identifier>PMID: 910129</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Drug carriers ; Erythrocyte membrane ; Erythrocyte Membrane - metabolism ; Erythrocytes ; Erythrocytes - metabolism ; Esters ; Fatty acids ; Fatty Acids, Unsaturated - blood ; Heterozygote ; Humans ; Lipids ; Membrane Lipids - blood ; Muscular diseases ; Muscular dystrophies ; Muscular Dystrophies - blood ; Muscular Dystrophies - genetics ; P branes ; Triglycerides ; Triglycerides - blood</subject><ispartof>Science (American Association for the Advancement of Science), 1977-10, Vol.198 (4314), p.309-310</ispartof><rights>Copyright 1977 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-81d4984f1b1ad0ea8a1a6a1a9aa5d0068fc7069c3f2ea5949394f1747c236333</citedby><cites>FETCH-LOGICAL-c340t-81d4984f1b1ad0ea8a1a6a1a9aa5d0068fc7069c3f2ea5949394f1747c236333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1744594$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1744594$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/910129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Howland, John L.</creatorcontrib><creatorcontrib>Iyer, Susheela L.</creatorcontrib><title>Erythrocyte Lipids in Heterozygous Carriers of Duchenne Muscular Dystrophy</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Erythrocyte membranes from heterozygous carriers of Duchenne muscular dystrophy exhibit a diminished amount of palmitoleic acid when compared to membranes from normal subjects. A similar, but more variable, diminution is observed in the case of patients with this disorder. The change in fatty acid composition appears related to a low membrane triglyceride content and may provide both a possible technique for carrier detection and a clue regarding pathogenesis.</description><subject>Drug carriers</subject><subject>Erythrocyte membrane</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Erythrocytes</subject><subject>Erythrocytes - metabolism</subject><subject>Esters</subject><subject>Fatty acids</subject><subject>Fatty Acids, Unsaturated - blood</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Lipids</subject><subject>Membrane Lipids - blood</subject><subject>Muscular diseases</subject><subject>Muscular dystrophies</subject><subject>Muscular Dystrophies - blood</subject><subject>Muscular Dystrophies - genetics</subject><subject>P branes</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkL1PwzAUxC3EVymsTAye2FKeY8eJR9SWLxWxdI9c54WmSuNgO0P460mVCiSGpzfc706nI-SWwYyxWD54U2FjcKYYsFidkAkDlUQqBn5KJgBcRhmkySW58n4HMGiKX5DzkZ6Qt6Xrw9ZZ0wekq6qtCk-rhr5gQGe_-0_beTrXzlXoPLUlXXRmi02D9L3zpqu1o4veB2fbbX9Nzkpde7w5_ilZPy3X85do9fH8On9cRYYLCFHGCqEyUbIN0wWgzjTTcjildVIAyKw0KUhleBmjTpRQXA1wKlITc8k5n5L7MbZ19qtDH_J95Q3WtW5waJunXKpYyAM4G0HjrPcOy7x11V67PmeQH6bLj9Pl4xiD4e6Y3G32WPzi_-WdD9b9haVCDDX5D2DcdOc</recordid><startdate>19771021</startdate><enddate>19771021</enddate><creator>Howland, John L.</creator><creator>Iyer, Susheela L.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19771021</creationdate><title>Erythrocyte Lipids in Heterozygous Carriers of Duchenne Muscular Dystrophy</title><author>Howland, John L. ; Iyer, Susheela L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-81d4984f1b1ad0ea8a1a6a1a9aa5d0068fc7069c3f2ea5949394f1747c236333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Drug carriers</topic><topic>Erythrocyte membrane</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Erythrocytes</topic><topic>Erythrocytes - metabolism</topic><topic>Esters</topic><topic>Fatty acids</topic><topic>Fatty Acids, Unsaturated - blood</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Lipids</topic><topic>Membrane Lipids - blood</topic><topic>Muscular diseases</topic><topic>Muscular dystrophies</topic><topic>Muscular Dystrophies - blood</topic><topic>Muscular Dystrophies - genetics</topic><topic>P branes</topic><topic>Triglycerides</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Howland, John L.</creatorcontrib><creatorcontrib>Iyer, Susheela L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Howland, John L.</au><au>Iyer, Susheela L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Erythrocyte Lipids in Heterozygous Carriers of Duchenne Muscular Dystrophy</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1977-10-21</date><risdate>1977</risdate><volume>198</volume><issue>4314</issue><spage>309</spage><epage>310</epage><pages>309-310</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Erythrocyte membranes from heterozygous carriers of Duchenne muscular dystrophy exhibit a diminished amount of palmitoleic acid when compared to membranes from normal subjects. A similar, but more variable, diminution is observed in the case of patients with this disorder. The change in fatty acid composition appears related to a low membrane triglyceride content and may provide both a possible technique for carrier detection and a clue regarding pathogenesis.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>910129</pmid><doi>10.1126/science.910129</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1977-10, Vol.198 (4314), p.309-310 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73692463 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Drug carriers Erythrocyte membrane Erythrocyte Membrane - metabolism Erythrocytes Erythrocytes - metabolism Esters Fatty acids Fatty Acids, Unsaturated - blood Heterozygote Humans Lipids Membrane Lipids - blood Muscular diseases Muscular dystrophies Muscular Dystrophies - blood Muscular Dystrophies - genetics P branes Triglycerides Triglycerides - blood |
| title | Erythrocyte Lipids in Heterozygous Carriers of Duchenne Muscular Dystrophy |
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