Erythrocyte Lipids in Heterozygous Carriers of Duchenne Muscular Dystrophy

Erythrocyte membranes from heterozygous carriers of Duchenne muscular dystrophy exhibit a diminished amount of palmitoleic acid when compared to membranes from normal subjects. A similar, but more variable, diminution is observed in the case of patients with this disorder. The change in fatty acid c...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1977-10, Vol.198 (4314), p.309-310
Hauptverfasser:	Howland, John L., Iyer, Susheela L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug carriers Erythrocyte membrane Erythrocyte Membrane - metabolism Erythrocytes Erythrocytes - metabolism Esters Fatty acids Fatty Acids, Unsaturated - blood Heterozygote Humans Lipids Membrane Lipids - blood Muscular diseases Muscular dystrophies Muscular Dystrophies - blood Muscular Dystrophies - genetics P branes Triglycerides Triglycerides - blood
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Beschreibung
Zusammenfassung:	Erythrocyte membranes from heterozygous carriers of Duchenne muscular dystrophy exhibit a diminished amount of palmitoleic acid when compared to membranes from normal subjects. A similar, but more variable, diminution is observed in the case of patients with this disorder. The change in fatty acid composition appears related to a low membrane triglyceride content and may provide both a possible technique for carrier detection and a clue regarding pathogenesis.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.910129