Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 3. .omega.-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)alkanoic acids

Omega-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)butyric, -hexanoic, and -octanoic acids were evaluated in the carrageenan paw edema assay. The most active compound, the butyric acid analogue, was 1.80 times more potent than the hexanoic compound, 1.15 times more potent than the octanoic analogue, a...

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Veröffentlicht in:	Journal of medicinal chemistry 1977-11, Vol.20 (11), p.1499-1501
Hauptverfasser:	Aultz, Daniel E, McFadden, Arthur R, Lassman, Howard B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - therapeutic use Carboxylic Acids - chemical synthesis Carboxylic Acids - therapeutic use Dibenzoxepins - chemical synthesis Dibenzoxepins - therapeutic use Edema - drug therapy Rats Structure-Activity Relationship
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Zusammenfassung:	Omega-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)butyric, -hexanoic, and -octanoic acids were evaluated in the carrageenan paw edema assay. The most active compound, the butyric acid analogue, was 1.80 times more potent than the hexanoic compound, 1.15 times more potent than the octanoic analogue, and 0.43 times as potent as indomethacin.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00221a028