4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents
Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive eff...
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| Veröffentlicht in: | Journal of medicinal chemistry 1977-11, Vol.20 (11), p.1520-1521 |
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| container_title | Journal of medicinal chemistry |
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| creator | Warren, James D Woodward, David L Hargreaves, Ronald T |
| description | Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive effects when orally administered. The same compounds were not hypotensive in the normotensive dog. |
| doi_str_mv | 10.1021/jm00221a034 |
| format | Article |
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Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive effects when orally administered. The same compounds were not hypotensive in the normotensive dog.</description><identifier>ISSN: 0022-2623</identifier><identifier>EISSN: 1520-4804</identifier><identifier>DOI: 10.1021/jm00221a034</identifier><identifier>PMID: 915918</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Antihypertensive Agents - chemical synthesis ; Antihypertensive Agents - therapeutic use ; Benzaldehydes - chemical synthesis ; Benzaldehydes - therapeutic use ; Dogs ; Hypertension - drug therapy ; Rats ; Semicarbazones - chemical synthesis ; Semicarbazones - therapeutic use ; Structure-Activity Relationship</subject><ispartof>Journal of medicinal chemistry, 1977-11, Vol.20 (11), p.1520-1521</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a268t-524d3f814c1b468434a4cd0be1033f7e781de6585efc0d07fbc6926f787103ca3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jm00221a034$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jm00221a034$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/915918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warren, James D</creatorcontrib><creatorcontrib>Woodward, David L</creatorcontrib><creatorcontrib>Hargreaves, Ronald T</creatorcontrib><title>4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. Chem</addtitle><description>Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive effects when orally administered. The same compounds were not hypotensive in the normotensive dog.</description><subject>Animals</subject><subject>Antihypertensive Agents - chemical synthesis</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Benzaldehydes - chemical synthesis</subject><subject>Benzaldehydes - therapeutic use</subject><subject>Dogs</subject><subject>Hypertension - drug therapy</subject><subject>Rats</subject><subject>Semicarbazones - chemical synthesis</subject><subject>Semicarbazones - therapeutic use</subject><subject>Structure-Activity Relationship</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1P3DAQhq0KSpdtT1w55AQHlNZfcZwjIL4kJKou7aEXy7EnbLaJvdgOYvfXNygIcUAaaaR5H70jPQgdEPydYEp-rHqMKSUaM_4JzUhBcc4l5jto9nLPqaDsC9qPcYUxZoSyPfS5IkVF5Az95fliqGNq05DAZhH61uhQ6613EDPfZL13Ps-0s5ltzbLzwdfgtrqzsNzYEdHjuNQuN2sICVxsnyDTD-BS_Ip2G91F-Pa65-j35cX9-XV-e3d1c356m2sqZMoLyi1rJOGG1FxIzrjmxuIaCGasKaGUxIIoZAGNwRaXTW1ERUVTynIkjGZzdDT1roN_HCAm1bfRQNdpB36IqmRCikJUI3gygSb4GAM0ah3aXoeNIli9iFTvRI704WvtUPdg39jJ3BjnU9zGBM9vqQ7_lChZWaj7nwslfi04rv6cqcuRP554baJa-SG40cmHj_8D076KMg</recordid><startdate>19771101</startdate><enddate>19771101</enddate><creator>Warren, James D</creator><creator>Woodward, David L</creator><creator>Hargreaves, Ronald T</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19771101</creationdate><title>4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents</title><author>Warren, James D ; Woodward, David L ; Hargreaves, Ronald T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a268t-524d3f814c1b468434a4cd0be1033f7e781de6585efc0d07fbc6926f787103ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Antihypertensive Agents - chemical synthesis</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Benzaldehydes - chemical synthesis</topic><topic>Benzaldehydes - therapeutic use</topic><topic>Dogs</topic><topic>Hypertension - drug therapy</topic><topic>Rats</topic><topic>Semicarbazones - chemical synthesis</topic><topic>Semicarbazones - therapeutic use</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warren, James D</creatorcontrib><creatorcontrib>Woodward, David L</creatorcontrib><creatorcontrib>Hargreaves, Ronald T</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warren, James D</au><au>Woodward, David L</au><au>Hargreaves, Ronald T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents</atitle><jtitle>Journal of medicinal chemistry</jtitle><addtitle>J. Med. Chem</addtitle><date>1977-11-01</date><risdate>1977</risdate><volume>20</volume><issue>11</issue><spage>1520</spage><epage>1521</epage><pages>1520-1521</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><abstract>Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive effects when orally administered. The same compounds were not hypotensive in the normotensive dog.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>915918</pmid><doi>10.1021/jm00221a034</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of medicinal chemistry, 1977-11, Vol.20 (11), p.1520-1521 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73686569 |
| source | ACS Publications; MEDLINE |
| subjects | Animals Antihypertensive Agents - chemical synthesis Antihypertensive Agents - therapeutic use Benzaldehydes - chemical synthesis Benzaldehydes - therapeutic use Dogs Hypertension - drug therapy Rats Semicarbazones - chemical synthesis Semicarbazones - therapeutic use Structure-Activity Relationship |
| title | 4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents |
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