4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents

Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive eff...

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Veröffentlicht in:	Journal of medicinal chemistry 1977-11, Vol.20 (11), p.1520-1521
Hauptverfasser:	Warren, James D, Woodward, David L, Hargreaves, Ronald T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - chemical synthesis Antihypertensive Agents - therapeutic use Benzaldehydes - chemical synthesis Benzaldehydes - therapeutic use Dogs Hypertension - drug therapy Rats Semicarbazones - chemical synthesis Semicarbazones - therapeutic use Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive effects when orally administered. The same compounds were not hypotensive in the normotensive dog.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00221a034