Ocular abnormalities in the myopathic hamster (UM-X7.1 strain)

Ocular abnormalities in the myopathic hamster (UM-X7.1 strain)

Eyes from cardiomyopathic hamsters (UM-X7.1 strain) were examined histologically for evidence of ocular defects. Changes observed included microphthalmia, scleral ectasia, scleral rupture, keratoconus, retinal detachment, retinal dysplasia, retinal fragmentation, retinal thinning, fibrosis of iris a...

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Veröffentlicht in:Investigative ophthalmology & visual science 1977-11, Vol.16 (11), p.1047-1052
Hauptverfasser: Thakar, JH, Percy, DH, Strickland, KP
Format: Artikel
Sprache:eng
Schlagworte:
Age Factors
Animals
Cardiomyopathies - genetics
Cricetinae - genetics
Eye Abnormalities
Keratoconus - complications
Lens Diseases - complications
Microphthalmos - complications
Muscular Dystrophy, Animal - genetics
Sclera
Uveal Diseases - complications
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Zusammenfassung:Eyes from cardiomyopathic hamsters (UM-X7.1 strain) were examined histologically for evidence of ocular defects. Changes observed included microphthalmia, scleral ectasia, scleral rupture, keratoconus, retinal detachment, retinal dysplasia, retinal fragmentation, retinal thinning, fibrosis of iris and ciliary body, ectopia lentis, and cataract formation. Lesions characteristic of cardiomyopathic hamsters were observed in the myocardium and skeletal muscle. This strain may be a suitable animal model to study the pathogenesis of ocular changes seen in certain congenital connective tissue disorders in man.
ISSN:0146-0404
1552-5783