HIDden targets of microRNAs for growth control

How is the size of an animal determined? Why is it that humans grow larger than mice? Certainly, one of the most astonishing features of animal development is that every animal of a given species, and its organs and appendages, grow to approximately the same size. Surprisingly little is known about...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2003-09, Vol.28 (9), p.461-463
Hauptverfasser:	Bergmann, Andreas, Lane, Mary Ellen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Base Sequence Cell Division - physiology Gene Expression Regulation, Developmental - genetics Growth - genetics MicroRNAs - genetics MicroRNAs - metabolism Molecular Sequence Data Nucleic Acid Conformation Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism
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Beschreibung
Zusammenfassung:	How is the size of an animal determined? Why is it that humans grow larger than mice? Certainly, one of the most astonishing features of animal development is that every animal of a given species, and its organs and appendages, grow to approximately the same size. Surprisingly little is known about the biology of tissue growth and size control. Recent advances in Drosophila research have implicated a microRNA as an important regulator of animal size. These studies reveal an unexpected layer of size regulation in higher animals.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/S0968-0004(03)00175-0