Sites of Prostaglandin Synthesis in the Bovine Heart and Isolated Bovine Coronary Microvessels

Metabolically active coronary microvessels (generally < 100 fim in diameter) were isolated from bovine hearts. These preparations were virtually free of contaminating myocytes and consisted of a mixture of arterioles, venules, capillaries, and collagen fibers. The prostaglandin biosynthetic capac...

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Veröffentlicht in:	Circulation research 1981-11, Vol.49 (5), p.1152-1163
Hauptverfasser:	GERRITSEN, MARY E, PRINTZ, MORTON P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Coronary Vessels - metabolism Microcirculation Myocardium - metabolism Prostaglandin Endoperoxides - metabolism Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins - biosynthesis Prostaglandins D - metabolism Prostaglandins E - metabolism Prostaglandins F - metabolism Prostaglandins H - metabolism
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Zusammenfassung:	Metabolically active coronary microvessels (generally < 100 fim in diameter) were isolated from bovine hearts. These preparations were virtually free of contaminating myocytes and consisted of a mixture of arterioles, venules, capillaries, and collagen fibers. The prostaglandin biosynthetic capacity of isolated coronary micro vessels was assessed by quantitating conversion of C-arachidonic acid and C-prostaglandin endoperoxide (PGH2) to prostaglandins. Coronary microvessels were found to exhibit low cyclooxygenase activity, i.e., minimal conversion (
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.49.5.1152