Natural products--a simple model to explain chemical diversity

Natural products--a simple model to explain chemical diversity

A simple evolutionary model is presented which explains why organisms produce so many natural products, why so many have low biological activity, why enzymes involved in natural product synthesis have the properties they do and why natural product metabolism is shaped as it is.

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Bibliographische Detailangaben
Veröffentlicht in:Natural product reports 2003-08, Vol.20 (4), p.382-391
Hauptverfasser: Firn, Richard D, Jones, Clive G
Format: Artikel
Sprache:eng
Schlagworte:
Biodiversity
Biological Evolution
Biological Products
Models, Biological
Molecular Structure
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Beschreibung
Zusammenfassung:A simple evolutionary model is presented which explains why organisms produce so many natural products, why so many have low biological activity, why enzymes involved in natural product synthesis have the properties they do and why natural product metabolism is shaped as it is.
ISSN:0265-0568
1460-4752
DOI:10.1039/b208815k