Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis
Analysis of the hydrocarbons produced during catalysis by mutants of aristolochene synthase from Penicillium roqueforti indicated that Trp 334 had a pivotal function for the efficient production of aristolochene from farnesylpyrophosphate most likely by stabilising the intermediate, eudesmane cation...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2003-09 (17), p.2162-2163 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Deligeorgopoulou, Athina Taylor, Susan E Forcat, Silvia Allemann, Rudolf K |
| description | Analysis of the hydrocarbons produced during catalysis by mutants of aristolochene synthase from Penicillium roqueforti indicated that Trp 334 had a pivotal function for the efficient production of aristolochene from farnesylpyrophosphate most likely by stabilising the intermediate, eudesmane cation. |
| doi_str_mv | 10.1039/b306867f |
| format | Article |
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| ispartof | Chemical communications (Cambridge, England), 2003-09 (17), p.2162-2163 |
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| language | eng |
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| source | Royal Society of Chemistry Journals Archive (1841-2007); MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Catalysis Cations Isomerases - metabolism Penicillium - enzymology Penicillium - genetics Polyisoprenyl Phosphates - chemistry Sesquiterpenes - chemistry Sesquiterpenes, Eudesmane Tryptophan - chemistry |
| title | Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis |
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