Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis

Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis

Analysis of the hydrocarbons produced during catalysis by mutants of aristolochene synthase from Penicillium roqueforti indicated that Trp 334 had a pivotal function for the efficient production of aristolochene from farnesylpyrophosphate most likely by stabilising the intermediate, eudesmane cation...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2003-09 (17), p.2162-2163
Hauptverfasser: Deligeorgopoulou, Athina, Taylor, Susan E, Forcat, Silvia, Allemann, Rudolf K
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Cations
Isomerases - metabolism
Penicillium - enzymology
Penicillium - genetics
Polyisoprenyl Phosphates - chemistry
Sesquiterpenes - chemistry
Sesquiterpenes, Eudesmane
Tryptophan - chemistry
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Beschreibung
Zusammenfassung:Analysis of the hydrocarbons produced during catalysis by mutants of aristolochene synthase from Penicillium roqueforti indicated that Trp 334 had a pivotal function for the efficient production of aristolochene from farnesylpyrophosphate most likely by stabilising the intermediate, eudesmane cation.
ISSN:1359-7345
DOI:10.1039/b306867f