Enhancement of the transfer of alpha-tocopherol between liposomes and mitochondria by rat-liver protein(s)

α‐Tocopherol transfer from liposomes to mitochondria was enhanced by a cytosolic protein in rat liver. This protein was separated from the exchange protein specific for phosphatidylcholine. The stimulation was specific for α‐tocopherol and the ‘affinity’ order of tocopherols for the cytosolic protei...

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Veröffentlicht in:European journal of biochemistry 1981-07, Vol.117 (3), p.537-542
Hauptverfasser: Mowri, H, Nakagawa, Y, Inoue, K, Nojima, S. (Tokyo Univ. (Japan). Faculty of Pharmaceutical Sciences. Dept. of Health Chemistry)
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Sprache:eng
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Zusammenfassung:α‐Tocopherol transfer from liposomes to mitochondria was enhanced by a cytosolic protein in rat liver. This protein was separated from the exchange protein specific for phosphatidylcholine. The stimulation was specific for α‐tocopherol and the ‘affinity’ order of tocopherols for the cytosolic protein was found to be as follows: α‐tocopherol > γ‐tocopherol ≫α‐tocopheryl acetate, α‐tocopherol quinone. The transfer‐stimulating protein may act as a carrier, since an intermediate (α‐tocopherol)‐protein complex could be detected when liposomes containing α‐tocopherol were incubated with the cytosol. This transfer‐stimulating activity was present not only in liver, but also in heart, spleen and lung.
ISSN:0014-2956
1432-1033
DOI:10.1111/j.1432-1033.1981.tb06370.x