In vitro evaluation of Bacopa monniera on anti- Helicobacter pylori activity and accumulation of prostaglandins
Bacopa monnierais an Indian tratidional medicine widely used to improve intellectual functions. Earlier, we had reported the prophylactic and curative effects of standardized extract of Bacopa monniera(BME) in various gastric ulcer models. The effect was due to augmentation of the defensive mucosal...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2003-01, Vol.10 (6), p.523-527 |
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| creator | Goel, R.K. Sairam, K. Dora Babu, M. Tavares, I.A. Raman, A. |
| description | Bacopa monnierais an Indian tratidional medicine widely used to improve intellectual functions. Earlier, we had reported the prophylactic and curative effects of standardized extract of
Bacopa monniera(BME) in various gastric ulcer models. The effect was due to augmentation of the defensive mucosal factors like increase in mucin secretion, life span of mucosal cells and gastric antioxidant effect rather than on the offensive acid-pepsin secretion. The present study includes evaluation of standardized BME(bacoside Acontent – 35.5 ± 0.9) on other contributing factors towards ulcerogenesis. BMEin the dose of 1000 μg/ml showed anti-
Helicobacter pylori activity
in vitroI and in the dose of 10 μg/ml increased
in vitro of prostanoids (PGE and PGI
2) in human colonic mucosal incubates. It may be concluded that these factors may contribute to antiulcerogenic activity of BME. |
| doi_str_mv | 10.1078/094471103322331494 |
| format | Article |
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Bacopa monniera(BME) in various gastric ulcer models. The effect was due to augmentation of the defensive mucosal factors like increase in mucin secretion, life span of mucosal cells and gastric antioxidant effect rather than on the offensive acid-pepsin secretion. The present study includes evaluation of standardized BME(bacoside Acontent – 35.5 ± 0.9) on other contributing factors towards ulcerogenesis. BMEin the dose of 1000 μg/ml showed anti-
Helicobacter pylori activity
in vitroI and in the dose of 10 μg/ml increased
in vitro of prostanoids (PGE and PGI
2) in human colonic mucosal incubates. It may be concluded that these factors may contribute to antiulcerogenic activity of BME.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1078/094471103322331494</identifier><identifier>PMID: 13678238</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Anti-Infective Agents - administration & dosage ; Anti-Infective Agents - pharmacology ; Anti-Infective Agents - therapeutic use ; Antiulcer drugs ; antiulcerogenic ; Bacopa ; Bacopa monniera ; bacoside-A ; Drug therapy ; Epoprostenol - metabolism ; Evaluation ; gastric mucosal offensive and defensive factors ; Helicobacter infections ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Helicobacter pylori - drug effects ; Humans ; India ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - metabolism ; Materia medica, Vegetable ; Medicinal plants ; Medicine, Traditional ; Microbial Sensitivity Tests ; Organometallic Compounds - pharmacology ; Phytotherapy ; Plant extracts ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; prostaglandins ; Prostaglandins E - metabolism ; Statistics ; Stomach Ulcer - drug therapy</subject><ispartof>Phytomedicine (Stuttgart), 2003-01, Vol.10 (6), p.523-527</ispartof><rights>2003 Urban & Fischer Verlag</rights><rights>COPYRIGHT 2003 Urban & Fischer Verlag</rights><rights>Copyright Urban & Fischer Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-628b18e6083813647d7e5f9138c74be133f6f32c822eedf9fb56ca7e8840a9823</citedby><cites>FETCH-LOGICAL-c456t-628b18e6083813647d7e5f9138c74be133f6f32c822eedf9fb56ca7e8840a9823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/205538539?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994,64384,64386,64388,72340</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13678238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goel, R.K.</creatorcontrib><creatorcontrib>Sairam, K.</creatorcontrib><creatorcontrib>Dora Babu, M.</creatorcontrib><creatorcontrib>Tavares, I.A.</creatorcontrib><creatorcontrib>Raman, A.</creatorcontrib><title>In vitro evaluation of Bacopa monniera on anti- Helicobacter pylori activity and accumulation of prostaglandins</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Bacopa monnierais an Indian tratidional medicine widely used to improve intellectual functions. Earlier, we had reported the prophylactic and curative effects of standardized extract of
Bacopa monniera(BME) in various gastric ulcer models. The effect was due to augmentation of the defensive mucosal factors like increase in mucin secretion, life span of mucosal cells and gastric antioxidant effect rather than on the offensive acid-pepsin secretion. The present study includes evaluation of standardized BME(bacoside Acontent – 35.5 ± 0.9) on other contributing factors towards ulcerogenesis. BMEin the dose of 1000 μg/ml showed anti-
Helicobacter pylori activity
in vitroI and in the dose of 10 μg/ml increased
in vitro of prostanoids (PGE and PGI
2) in human colonic mucosal incubates. It may be concluded that these factors may contribute to antiulcerogenic activity of BME.</description><subject>Anti-Infective Agents - administration & dosage</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>Antiulcer drugs</subject><subject>antiulcerogenic</subject><subject>Bacopa</subject><subject>Bacopa monniera</subject><subject>bacoside-A</subject><subject>Drug therapy</subject><subject>Epoprostenol - metabolism</subject><subject>Evaluation</subject><subject>gastric mucosal offensive and defensive factors</subject><subject>Helicobacter infections</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - drug effects</subject><subject>Humans</subject><subject>India</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Materia medica, Vegetable</subject><subject>Medicinal plants</subject><subject>Medicine, Traditional</subject><subject>Microbial Sensitivity Tests</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Phytotherapy</subject><subject>Plant extracts</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>prostaglandins</subject><subject>Prostaglandins E - metabolism</subject><subject>Statistics</subject><subject>Stomach Ulcer - drug therapy</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9rFTEUxYMo9rX6BVzI4MLd1PybSQbc1KJtoeBGwV3IZG4eKZnkmcw8eN_eW95DQYtkEXLzOycn9xLyhtFLRpX-QAcpFWNUCM6FYHKQz8iG9Uy3dOh-PCebR6BFQpyR81ofKEVG0ZfkjIleaS70huS71OzDUnIDextXu4ScmuybT9blnW3mnFKAYhus2rSEtrmFGFwerVugNLtDzCU0eAhockBkwoNb5zX-dtqVXBe7jXgXUn1FXngbK7w-7Rfk-5fP365v2_uvN3fXV_etk12_tD3XI9PQUy00hpVqUtD5gQntlByBCeF7L7jTnANMfvBj1zurQGtJ7YBfuyDvj774_M8V6mLmUB1EjAF5rUaJvhu4Ugi--wt8yGtJmM1w2nVCd2JAqD1CWxvBhOTzUqzbQsLWxJzAByxfMTpQ3stOIn_5BI9rghm795SAHwUOu1ULeLMrYbblYBg1j8M2_w4bRW9P0ddxhumP5DRdBD4eAcBO73GOproAycEUCrjFTDn8z_8XfQy2iA</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Goel, R.K.</creator><creator>Sairam, K.</creator><creator>Dora Babu, M.</creator><creator>Tavares, I.A.</creator><creator>Raman, A.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20030101</creationdate><title>In vitro evaluation of Bacopa monniera on anti- Helicobacter pylori activity and accumulation of prostaglandins</title><author>Goel, R.K. ; Sairam, K. ; Dora Babu, M. ; Tavares, I.A. ; Raman, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-628b18e6083813647d7e5f9138c74be133f6f32c822eedf9fb56ca7e8840a9823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anti-Infective Agents - administration & dosage</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>Antiulcer drugs</topic><topic>antiulcerogenic</topic><topic>Bacopa</topic><topic>Bacopa monniera</topic><topic>bacoside-A</topic><topic>Drug therapy</topic><topic>Epoprostenol - metabolism</topic><topic>Evaluation</topic><topic>gastric mucosal offensive and defensive factors</topic><topic>Helicobacter infections</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - drug effects</topic><topic>Humans</topic><topic>India</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Materia medica, Vegetable</topic><topic>Medicinal plants</topic><topic>Medicine, Traditional</topic><topic>Microbial Sensitivity Tests</topic><topic>Organometallic Compounds - pharmacology</topic><topic>Phytotherapy</topic><topic>Plant extracts</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>prostaglandins</topic><topic>Prostaglandins E - metabolism</topic><topic>Statistics</topic><topic>Stomach Ulcer - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goel, R.K.</creatorcontrib><creatorcontrib>Sairam, K.</creatorcontrib><creatorcontrib>Dora Babu, M.</creatorcontrib><creatorcontrib>Tavares, I.A.</creatorcontrib><creatorcontrib>Raman, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goel, R.K.</au><au>Sairam, K.</au><au>Dora Babu, M.</au><au>Tavares, I.A.</au><au>Raman, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro evaluation of Bacopa monniera on anti- Helicobacter pylori activity and accumulation of prostaglandins</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>10</volume><issue>6</issue><spage>523</spage><epage>527</epage><pages>523-527</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>Bacopa monnierais an Indian tratidional medicine widely used to improve intellectual functions. Earlier, we had reported the prophylactic and curative effects of standardized extract of
Bacopa monniera(BME) in various gastric ulcer models. The effect was due to augmentation of the defensive mucosal factors like increase in mucin secretion, life span of mucosal cells and gastric antioxidant effect rather than on the offensive acid-pepsin secretion. The present study includes evaluation of standardized BME(bacoside Acontent – 35.5 ± 0.9) on other contributing factors towards ulcerogenesis. BMEin the dose of 1000 μg/ml showed anti-
Helicobacter pylori activity
in vitroI and in the dose of 10 μg/ml increased
in vitro of prostanoids (PGE and PGI
2) in human colonic mucosal incubates. It may be concluded that these factors may contribute to antiulcerogenic activity of BME.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>13678238</pmid><doi>10.1078/094471103322331494</doi><tpages>5</tpages></addata></record> |
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| ispartof | Phytomedicine (Stuttgart), 2003-01, Vol.10 (6), p.523-527 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Antiulcer drugs antiulcerogenic Bacopa Bacopa monniera bacoside-A Drug therapy Epoprostenol - metabolism Evaluation gastric mucosal offensive and defensive factors Helicobacter infections Helicobacter Infections - drug therapy Helicobacter pylori Helicobacter pylori - drug effects Humans India Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Materia medica, Vegetable Medicinal plants Medicine, Traditional Microbial Sensitivity Tests Organometallic Compounds - pharmacology Phytotherapy Plant extracts Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use prostaglandins Prostaglandins E - metabolism Statistics Stomach Ulcer - drug therapy |
| title | In vitro evaluation of Bacopa monniera on anti- Helicobacter pylori activity and accumulation of prostaglandins |
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