In vitro evaluation of Bacopa monniera on anti- Helicobacter pylori activity and accumulation of prostaglandins

Bacopa monnierais an Indian tratidional medicine widely used to improve intellectual functions. Earlier, we had reported the prophylactic and curative effects of standardized extract of Bacopa monniera(BME) in various gastric ulcer models. The effect was due to augmentation of the defensive mucosal factors like increase in mucin secretion, life span of mucosal cells and gastric antioxidant effect rather than on the offensive acid-pepsin secretion. The present study includes evaluation of standardized BME(bacoside Acontent – 35.5 ± 0.9) on other contributing factors towards ulcerogenesis. BMEin the dose of 1000 μg/ml showed anti- Helicobacter pylori activity in vitroI and in the dose of 10 μg/ml increased in vitro of prostanoids (PGE and PGI 2) in human colonic mucosal incubates. It may be concluded that these factors may contribute to antiulcerogenic activity of BME.