Transplasmalemma NADH dehydrogenase is inhibited by actinomycin D
Actinomycin D and puromycin inhibit the NADH dehydrogenase activity of mouse liver and pig erythrocyte plasma membrane. Actinomycin is effective at 10 −6 M and inhibits the transmembrane ferricyanide reduction by whole erythrocytes. The NADH dehydrogenase of endoplasmic reticulum is not inhibited. P...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1981-01, Vol.101 (1), p.68-75 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Sun, Iris L. Crane, Frederick L. |
| description | Actinomycin D and puromycin inhibit the NADH dehydrogenase activity of mouse liver and pig erythrocyte plasma membrane. Actinomycin is effective at 10
−6 M and inhibits the transmembrane ferricyanide reduction by whole erythrocytes. The NADH dehydrogenase of endoplasmic reticulum is not inhibited. Puromycin inhibits the plasma membrane dehydrogenase but does not inhibit ferricyanide reduction by whole erythrocytes. Effects of these drugs on metabolism after short term exposure may be mediated through the plasma membrane dehydrogenase. |
| doi_str_mv | 10.1016/S0006-291X(81)80011-3 |
| format | Article |
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−6 M and inhibits the transmembrane ferricyanide reduction by whole erythrocytes. The NADH dehydrogenase of endoplasmic reticulum is not inhibited. Puromycin inhibits the plasma membrane dehydrogenase but does not inhibit ferricyanide reduction by whole erythrocytes. Effects of these drugs on metabolism after short term exposure may be mediated through the plasma membrane dehydrogenase.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/S0006-291X(81)80011-3</identifier><identifier>PMID: 7284008</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>actinomycin D ; Animals ; Cell Membrane - enzymology ; Cytochrome Reductases - antagonists & inhibitors ; Dactinomycin - pharmacology ; Endoplasmic Reticulum - enzymology ; Erythrocyte Membrane - enzymology ; erythrocytes ; Erythrocytes - enzymology ; Kinetics ; liver ; Liver - enzymology ; Mice ; NADH dehydrogenase ; NADH Dehydrogenase - antagonists & inhibitors ; pigs ; plasma membranes ; puromycin</subject><ispartof>Biochemical and biophysical research communications, 1981-01, Vol.101 (1), p.68-75</ispartof><rights>1981 Academic Press, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-b0eb131c20350c751000b592cdb9d723911cfe44d5f23d5957abc679555414533</citedby><cites>FETCH-LOGICAL-c422t-b0eb131c20350c751000b592cdb9d723911cfe44d5f23d5957abc679555414533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-291X(81)80011-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7284008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Iris L.</creatorcontrib><creatorcontrib>Crane, Frederick L.</creatorcontrib><title>Transplasmalemma NADH dehydrogenase is inhibited by actinomycin D</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Actinomycin D and puromycin inhibit the NADH dehydrogenase activity of mouse liver and pig erythrocyte plasma membrane. Actinomycin is effective at 10
−6 M and inhibits the transmembrane ferricyanide reduction by whole erythrocytes. The NADH dehydrogenase of endoplasmic reticulum is not inhibited. Puromycin inhibits the plasma membrane dehydrogenase but does not inhibit ferricyanide reduction by whole erythrocytes. Effects of these drugs on metabolism after short term exposure may be mediated through the plasma membrane dehydrogenase.</description><subject>actinomycin D</subject><subject>Animals</subject><subject>Cell Membrane - enzymology</subject><subject>Cytochrome Reductases - antagonists & inhibitors</subject><subject>Dactinomycin - pharmacology</subject><subject>Endoplasmic Reticulum - enzymology</subject><subject>Erythrocyte Membrane - enzymology</subject><subject>erythrocytes</subject><subject>Erythrocytes - enzymology</subject><subject>Kinetics</subject><subject>liver</subject><subject>Liver - enzymology</subject><subject>Mice</subject><subject>NADH dehydrogenase</subject><subject>NADH Dehydrogenase - antagonists & inhibitors</subject><subject>pigs</subject><subject>plasma membranes</subject><subject>puromycin</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUlPwzAQhS0EgrL8BKScEBwCHi9ZTqhilxAcKBI3y7En1ChLsVOk_HuStuoVTnOYb-Y9vUfIKdBLoJBcvVFKk5jl8HGewUVGKUDMd8gEaE5jBlTskskWOSCHIXyNjEjyfbKfskxQmk3IdOZ1ExaVDrWusK519DK9fYwsznvr209sdMDIhcg1c1e4Dm1U9JE2nWvaujeuiW6PyV6pq4Anm3lE3u_vZjeP8fPrw9PN9Dk2grEuLigWwMEwyiU1qYTBWyFzZmyR25TxHMCUKISVJeNW5jLVhUnSXEopQEjOj8jZ-u_Ct99LDJ2qXTBYVbrBdhlUyhMpkuH9XyBICRK4-AcoOM-ADaBcg8a3IXgs1cK7WvteAVVjGWpVhhqTVhmoVRlqtHy6EVgWNdrt1Sb9YX-93uOQ249Dr4Jx2Bi0zqPplG3dHwq_QxCW-w</recordid><startdate>19810101</startdate><enddate>19810101</enddate><creator>Sun, Iris L.</creator><creator>Crane, Frederick L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19810101</creationdate><title>Transplasmalemma NADH dehydrogenase is inhibited by actinomycin D</title><author>Sun, Iris L. ; Crane, Frederick L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-b0eb131c20350c751000b592cdb9d723911cfe44d5f23d5957abc679555414533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>actinomycin D</topic><topic>Animals</topic><topic>Cell Membrane - enzymology</topic><topic>Cytochrome Reductases - antagonists & inhibitors</topic><topic>Dactinomycin - pharmacology</topic><topic>Endoplasmic Reticulum - enzymology</topic><topic>Erythrocyte Membrane - enzymology</topic><topic>erythrocytes</topic><topic>Erythrocytes - enzymology</topic><topic>Kinetics</topic><topic>liver</topic><topic>Liver - enzymology</topic><topic>Mice</topic><topic>NADH dehydrogenase</topic><topic>NADH Dehydrogenase - antagonists & inhibitors</topic><topic>pigs</topic><topic>plasma membranes</topic><topic>puromycin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Iris L.</creatorcontrib><creatorcontrib>Crane, Frederick L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Iris L.</au><au>Crane, Frederick L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transplasmalemma NADH dehydrogenase is inhibited by actinomycin D</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1981-01-01</date><risdate>1981</risdate><volume>101</volume><issue>1</issue><spage>68</spage><epage>75</epage><pages>68-75</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Actinomycin D and puromycin inhibit the NADH dehydrogenase activity of mouse liver and pig erythrocyte plasma membrane. Actinomycin is effective at 10
−6 M and inhibits the transmembrane ferricyanide reduction by whole erythrocytes. The NADH dehydrogenase of endoplasmic reticulum is not inhibited. Puromycin inhibits the plasma membrane dehydrogenase but does not inhibit ferricyanide reduction by whole erythrocytes. Effects of these drugs on metabolism after short term exposure may be mediated through the plasma membrane dehydrogenase.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7284008</pmid><doi>10.1016/S0006-291X(81)80011-3</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1981-01, Vol.101 (1), p.68-75 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | actinomycin D Animals Cell Membrane - enzymology Cytochrome Reductases - antagonists & inhibitors Dactinomycin - pharmacology Endoplasmic Reticulum - enzymology Erythrocyte Membrane - enzymology erythrocytes Erythrocytes - enzymology Kinetics liver Liver - enzymology Mice NADH dehydrogenase NADH Dehydrogenase - antagonists & inhibitors pigs plasma membranes puromycin |
| title | Transplasmalemma NADH dehydrogenase is inhibited by actinomycin D |
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