Transplasmalemma NADH dehydrogenase is inhibited by actinomycin D

Actinomycin D and puromycin inhibit the NADH dehydrogenase activity of mouse liver and pig erythrocyte plasma membrane. Actinomycin is effective at 10 −6 M and inhibits the transmembrane ferricyanide reduction by whole erythrocytes. The NADH dehydrogenase of endoplasmic reticulum is not inhibited. P...

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Veröffentlicht in:	Biochemical and biophysical research communications 1981-01, Vol.101 (1), p.68-75
Hauptverfasser:	Sun, Iris L., Crane, Frederick L.
Format:	Artikel
Sprache:	eng
Schlagworte:	actinomycin D Animals Cell Membrane - enzymology Cytochrome Reductases - antagonists & inhibitors Dactinomycin - pharmacology Endoplasmic Reticulum - enzymology Erythrocyte Membrane - enzymology erythrocytes Erythrocytes - enzymology Kinetics liver Liver - enzymology Mice NADH dehydrogenase NADH Dehydrogenase - antagonists & inhibitors pigs plasma membranes puromycin
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Zusammenfassung:	Actinomycin D and puromycin inhibit the NADH dehydrogenase activity of mouse liver and pig erythrocyte plasma membrane. Actinomycin is effective at 10 −6 M and inhibits the transmembrane ferricyanide reduction by whole erythrocytes. The NADH dehydrogenase of endoplasmic reticulum is not inhibited. Puromycin inhibits the plasma membrane dehydrogenase but does not inhibit ferricyanide reduction by whole erythrocytes. Effects of these drugs on metabolism after short term exposure may be mediated through the plasma membrane dehydrogenase.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/S0006-291X(81)80011-3