Failure of estrogen to protect the substantia nigra pars compacta of female rats from lesion induced by 6-hydroxydopamine

The immunostaining for tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNpc) and in the ventral tegmental area (VTA) after intranigral infusion of 6-hydroxydopamine (6-OHDA, 6 μg/side) was analyzed in ovariectomized adult female Wistar rats. Estrogen replacement for 52 days (400-μg...

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Veröffentlicht in:	Brain research 2003-10, Vol.986 (1), p.200-205
Hauptverfasser:	Ferraz, Anete Curte, Xavier, Léder Leal, Hernandes, Sı́lvia, Sulzbach, Martha, Viola, Giordano Gubert, Anselmo-Franci, Janete A., Achaval, Matilde, Da Cunha, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - metabolism Estrogen Estrogens - pharmacology Female Medical sciences Neurology Neurons - drug effects Neurons - metabolism Neuroprotection Neuroprotective Agents - pharmacology Oxidopamine - pharmacology Parkinsonian Disorders - drug therapy Parkinsonian Disorders - metabolism Parkinsonian Disorders - physiopathology Parkinson’s disease Rats Rats, Wistar Substantia Nigra - drug effects Substantia Nigra - pathology Substantia Nigra - physiopathology Substantia nigra pars compacta Treatment Failure Tyrosine 3-Monooxygenase - metabolism Ventral Tegmental Area - drug effects Ventral Tegmental Area - pathology Ventral Tegmental Area - physiopathology
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Zusammenfassung:	The immunostaining for tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNpc) and in the ventral tegmental area (VTA) after intranigral infusion of 6-hydroxydopamine (6-OHDA, 6 μg/side) was analyzed in ovariectomized adult female Wistar rats. Estrogen replacement for 52 days (400-μg 17-β-estradiol capsules) did not prevent the loss of TH-immunoreactive cells induced by 6-OHDA in the SNpc. This result indicates that the neuroprotective effect of dopaminergic mesencephalic cells is not observed with long-term estrogen replacement.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(03)03198-6