Retrospective diagnosis of congenital cytomegalovirus infection and cortical maldevelopment

Congenital cytomegalovirus (CMV) infection can cause malformations of cortical development (MCD). It is difficult to establish CMV as a cause of MCD several months postpartum. This can now be done by detection of CMV DNA in dried blood spots (DBS test) on Guthrie cards. The authors used DBS tests to...

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Veröffentlicht in:Neurology 2003-09, Vol.61 (5), p.710-712
Hauptverfasser: ZUCCA, C, BINDA, S, BORGATTI, R, TRIULZI, F, RADICE, L, BUTTE, C, BARKHAUS, P. E, BARBI, M
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container_end_page 712
container_issue 5
container_start_page 710
container_title Neurology
container_volume 61
creator ZUCCA, C
BINDA, S
BORGATTI, R
TRIULZI, F
RADICE, L
BUTTE, C
BARKHAUS, P. E
BARBI, M
description Congenital cytomegalovirus (CMV) infection can cause malformations of cortical development (MCD). It is difficult to establish CMV as a cause of MCD several months postpartum. This can now be done by detection of CMV DNA in dried blood spots (DBS test) on Guthrie cards. The authors used DBS tests to assess 10 patients with MCD of unknown cause. Four of the 10 patients were positive for CMV.
doi_str_mv 10.1212/wnl.61.5.710
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subjects Biological and medical sciences
Cerebral Cortex - abnormalities
Cerebral Cortex - pathology
Child, Preschool
Cytomegalovirus Infections - congenital
Cytomegalovirus Infections - diagnosis
Female
Human viral diseases
Humans
Infant
Infectious diseases
Magnetic Resonance Imaging
Male
Medical sciences
Nervous System Malformations - diagnosis
Retrospective Studies
Viral diseases
Viral diseases of the nervous system
title Retrospective diagnosis of congenital cytomegalovirus infection and cortical maldevelopment
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