Retrospective diagnosis of congenital cytomegalovirus infection and cortical maldevelopment

Retrospective diagnosis of congenital cytomegalovirus infection and cortical maldevelopment

Congenital cytomegalovirus (CMV) infection can cause malformations of cortical development (MCD). It is difficult to establish CMV as a cause of MCD several months postpartum. This can now be done by detection of CMV DNA in dried blood spots (DBS test) on Guthrie cards. The authors used DBS tests to...

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Veröffentlicht in:Neurology 2003-09, Vol.61 (5), p.710-712
Hauptverfasser: ZUCCA, C, BINDA, S, BORGATTI, R, TRIULZI, F, RADICE, L, BUTTE, C, BARKHAUS, P. E, BARBI, M
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Cerebral Cortex - abnormalities
Cerebral Cortex - pathology
Child, Preschool
Cytomegalovirus Infections - congenital
Cytomegalovirus Infections - diagnosis
Female
Human viral diseases
Humans
Infant
Infectious diseases
Magnetic Resonance Imaging
Male
Medical sciences
Nervous System Malformations - diagnosis
Retrospective Studies
Viral diseases
Viral diseases of the nervous system
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Zusammenfassung:Congenital cytomegalovirus (CMV) infection can cause malformations of cortical development (MCD). It is difficult to establish CMV as a cause of MCD several months postpartum. This can now be done by detection of CMV DNA in dried blood spots (DBS test) on Guthrie cards. The authors used DBS tests to assess 10 patients with MCD of unknown cause. Four of the 10 patients were positive for CMV.
ISSN:0028-3878
1526-632X
DOI:10.1212/wnl.61.5.710