The trials and tribulations of producing the first genetically engineered drug
Fifty years ago, the determination of the structure of DNA sparked a genetic revolution. Here, I give a personal perspective of the challenges involved in the development of the first biological therapeutic resulting from this revolution: recombinant human insulin.
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| Veröffentlicht in: | Nature reviews. Drug discovery 2003-09, Vol.2 (9), p.747-751 |
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| container_end_page | 751 |
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| container_issue | 9 |
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| container_title | Nature reviews. Drug discovery |
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| creator | Johnson, Irving S. |
| description | Fifty years ago, the determination of the structure of DNA sparked a genetic revolution. Here, I give a personal perspective of the challenges involved in the development of the first biological therapeutic resulting from this revolution: recombinant human insulin. |
| doi_str_mv | 10.1038/nrd1179 |
| format | Article |
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| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biomedical and Life Sciences Biomedicine Biotechnology Biotechnology industry Cancer Research Dosage and administration Drug Design History, 20th Century Humans Identification and classification Insulin Insulin - chemical synthesis Insulin - genetics Insulin - history Medicinal Chemistry Molecular Medicine Pharmacology/Toxicology Protein Engineering - history Protein Engineering - legislation & jurisprudence Protein Engineering - methods Recombinant molecules Recombinant Proteins - chemical synthesis Recombinant Proteins - history timeline United States |
| title | The trials and tribulations of producing the first genetically engineered drug |
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