The trials and tribulations of producing the first genetically engineered drug

Fifty years ago, the determination of the structure of DNA sparked a genetic revolution. Here, I give a personal perspective of the challenges involved in the development of the first biological therapeutic resulting from this revolution: recombinant human insulin.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature reviews. Drug discovery 2003-09, Vol.2 (9), p.747-751
1. Verfasser:	Johnson, Irving S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Biotechnology Biotechnology industry Cancer Research Dosage and administration Drug Design History, 20th Century Humans Identification and classification Insulin Insulin - chemical synthesis Insulin - genetics Insulin - history Medicinal Chemistry Molecular Medicine Pharmacology/Toxicology Protein Engineering - history Protein Engineering - legislation & jurisprudence Protein Engineering - methods Recombinant molecules Recombinant Proteins - chemical synthesis Recombinant Proteins - history timeline United States
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Beschreibung
Zusammenfassung:	Fifty years ago, the determination of the structure of DNA sparked a genetic revolution. Here, I give a personal perspective of the challenges involved in the development of the first biological therapeutic resulting from this revolution: recombinant human insulin.
ISSN:	1474-1776 1474-1784
DOI:	10.1038/nrd1179