Gamma-aminobutyric acid system in rat oviduct

A considerable amount of gamma-aminobutyric acid (GABA) was found in the rat oviduct, representing over 2.5 times the amount present in the whole brain. The oviduct also contained L-glutamic acid decarboxylase, 4-aminobutyrate-2-oxoglutarate aminotransferase, and succinic semialdehyde-NAD+ oxidoredu...

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Veröffentlicht in:	The Journal of biological chemistry 1981-10, Vol.256 (19), p.9816-9819
1. Verfasser:	R MartÃn del Rio
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminobutyrate Transaminase - metabolism Animals Estrus Fallopian Tubes - metabolism Female gamma-Aminobutyric Acid - metabolism Genitalia, Female - metabolism Glutamate Decarboxylase - metabolism Hydrogen-Ion Concentration Kinetics Male Organ Specificity Postmortem Changes Pregnancy Rats Rats, Inbred Strains
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Zusammenfassung:	A considerable amount of gamma-aminobutyric acid (GABA) was found in the rat oviduct, representing over 2.5 times the amount present in the whole brain. The oviduct also contained L-glutamic acid decarboxylase, 4-aminobutyrate-2-oxoglutarate aminotransferase, and succinic semialdehyde-NAD+ oxidoreductase enzymes with properties similar to those of brain enzymes. The GABA oviduct level varied during the ovarian cycle. It was concluded that this amino acid is synthesized and degraded in the oviduct although its physiological significance has not yet been determined.
ISSN:	0021-9258 1083-351X
DOI:	10.1016/s0021-9258(19)68699-0