Dwarfism in the Pygmy: An Isolated Deficiency of Insulin-like Growth Factor I

Dwarfism in the Pygmy: An Isolated Deficiency of Insulin-like Growth Factor I

Insulin-like growth factors (IGFs) I and II, which are present in normal human beings, were measured in serum samples from 11 pygmies from the Central African Republic, 31 controls, and 12 patients with growth hormone deficiency. The mean serum concentration of IGF-I (±S.E.M.) was 68.6±8 ng per mill...

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Veröffentlicht in:The New England journal of medicine 1981-10, Vol.305 (17), p.965-968
Hauptverfasser: Merimee, Thomas J, Zapf, Jürgen, Froesch, E. Rudolf
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
African Continental Ancestry Group
Aged
Central African Republic
Dwarfism
Dwarfism - blood
Dwarfism, Pituitary - blood
Endocrinology
Growth factors
Growth Hormone - blood
Growth Hormone - deficiency
Growth hormones
Humans
Insulin
Insulin - blood
Insulin - deficiency
Insulin-like growth factor I
Insulin-like growth factor II
Insulin-like growth factors
Middle Aged
Peptides - blood
Peptides - deficiency
Physical growth
Rodents
Somatomedins - blood
Somatomedins - deficiency
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Zusammenfassung:Insulin-like growth factors (IGFs) I and II, which are present in normal human beings, were measured in serum samples from 11 pygmies from the Central African Republic, 31 controls, and 12 patients with growth hormone deficiency. The mean serum concentration of IGF-I (±S.E.M.) was 68.6±8 ng per milliliter in pygmies, as compared with 193±10 ng per milliliter in controls (P
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198110223051701