Medial preoptic area adrenergic receptors modulate glycemia and insulinemia in freely moving rats

In order to investigate the role of medial preoptic area (MPOA) adrenoceptors in regulation of plasma glucose and insulin secretion, we injected 40 nmol of noradrenaline, clonidine or isoproterenol into the MPOA of freely moving Wistar rats. The animals were fitted with chronic jugular catheters for...

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Veröffentlicht in:	Brain research 2003-09, Vol.985 (1), p.56-64
Hauptverfasser:	Fóscolo, Rodrigo Bastos, de Castro, Mauricio Gustavo Bravim, Marubayashi, Umeko, dos Reis, Adelina Martha, Coimbra, Cândido Celso
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Agents - pharmacology Adrenergic alpha-Agonists - administration & dosage Adrenergic alpha-Agonists - pharmacology Adrenergic beta-Agonists - administration & dosage Adrenergic beta-Agonists - pharmacology Animals Area Under Curve Biological and medical sciences Blood Glucose - drug effects Blood Glucose - metabolism Clonidine - administration & dosage Clonidine - pharmacology Fundamental and applied biological sciences. Psychology Glucose Guanethidine - pharmacology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Injections, Intraventricular Insulin Insulin - blood Isoproterenol - administration & dosage Isoproterenol - pharmacology Male Medial preoptic area Microinjections Movement Noradrenaline Norepinephrine - administration & dosage Norepinephrine - pharmacology Preoptic Area - drug effects Preoptic Area - physiology Rats Rats, Wistar Receptors, Adrenergic - drug effects Receptors, Adrenergic - metabolism Sympathetic Nervous System - physiology Time Factors Vertebrates: endocrinology
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Zusammenfassung:	In order to investigate the role of medial preoptic area (MPOA) adrenoceptors in regulation of plasma glucose and insulin secretion, we injected 40 nmol of noradrenaline, clonidine or isoproterenol into the MPOA of freely moving Wistar rats. The animals were fitted with chronic jugular catheters for blood sampling and unilateral intracerebral cannulae placed into MPOA. The results showed that noradrenaline injection into MPOA produced a rapid increase in plasma glucose levels and insulin secretion, reaching a peak at 15 min post stimulus (25% over basal, P
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(03)03158-5