Splitting the difference: the germline-somatic mutation debate on generating antibody diversity

In the debate about the mechanism for the generation of immunological diversity, the initial positions of both 'somaticists' and 'germliners' were diametrically opposed. Then, as data developed favoring first one and then the other side, concessions were made, until the final sol...

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Veröffentlicht in:Nature immunology 2003-09, Vol.4 (9), p.829-833
1. Verfasser: Silverstein, Arthur M
Format: Artikel
Sprache:eng
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Zusammenfassung:In the debate about the mechanism for the generation of immunological diversity, the initial positions of both 'somaticists' and 'germliners' were diametrically opposed. Then, as data developed favoring first one and then the other side, concessions were made, until the final solution showed that each had been at least partially correct.
ISSN:1529-2908
1529-2916
DOI:10.1038/ni0903-829