Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus

Six lanostane-type triterpene acids were isolated from the fruiting bodies of Piptoporus betulinus. They were identified as polyporenic acids A (1) and C (2), three derivatives of polyporenic acid A (3-5), and a novel compound, (+)-12 alpha,28-dihydroxy-3 alpha-(3'-hydroxy-3'-methylglutary...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2003-08, Vol.66 (8), p.1104-1106
Hauptverfasser:	Kamo, T, Asanoma, M, Shibata, H, Hirota, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory activity Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Biological and medical sciences carbon chemical structure disease models Ear Edema fruiting bodies General pharmacology lanostane Lanosterol - analogs & derivatives Lanosterol - chemistry Lanosterol - isolation & purification Lanosterol - pharmacology Medical sciences Methylation methylene Mice Molecular Structure mushrooms Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals Piptoporus betulinus plant extracts Polyporaceae Polyporaceae - chemistry polyporenic acid protons spectral analysis Stereoisomerism triterpene acids Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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Zusammenfassung:	Six lanostane-type triterpene acids were isolated from the fruiting bodies of Piptoporus betulinus. They were identified as polyporenic acids A (1) and C (2), three derivatives of polyporenic acid A (3-5), and a novel compound, (+)-12 alpha,28-dihydroxy-3 alpha-(3'-hydroxy-3'-methylglutaryloxy)-24-methyllanosta-8,24(31)-dien-26-oic acid (6). All these compounds suppressed the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced edema on mouse ears by 49-86% with a 400 nmol/ear application.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0300479