HIV-1 infection: fooling the gatekeeper

Why are humans particularly susceptible to HIV-1, whereas our monkey cousins are impervious to the virus? Part of the answer may lie with the virus' interaction with a cellular system of defense ( pages 1138–1143 ).

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Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2003-09, Vol.9 (9), p.1112-1113
1. Verfasser:	Cullen, Bryan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cancer Research Cyclophilin A - drug effects Cyclophilin A - metabolism Cyclosporine - pharmacology DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism Genetic Predisposition to Disease HIV Infections - metabolism HIV-1 - pathogenicity Humans Infectious Diseases Leukemia Virus, Murine - pathogenicity Metabolic Diseases Mice Molecular Medicine Neurosciences news-and-views Primates - physiology Proteins - genetics Proteins - metabolism Retroviridae - pathogenicity Virion - drug effects Virion - metabolism
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Beschreibung
Zusammenfassung:	Why are humans particularly susceptible to HIV-1, whereas our monkey cousins are impervious to the virus? Part of the answer may lie with the virus' interaction with a cellular system of defense ( pages 1138–1143 ).
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm0903-1112