Factors Associated with Maintenance of Long-Term Plasma Human Immunodeficiency Virus RNA Suppression

To analyze factors associated with long-term (⩾2 years) suppression of virus load (VL), we performed a nested case-control analysis of 1235 Human Immunodeficiency Virus Outpatient Study cohort participants who were well characterized by multiple VL and CD4+ cell count determinations. Of these patien...

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Veröffentlicht in:	Clinical infectious diseases 2003-09, Vol.37 (5), p.702-707
Hauptverfasser:	Holmberg, Scott D., Hamburger, Merle E., Moorman, Anne C., Wood, Kathy C., Palella, Frank J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active - methods Antiretrovirals Antiviral agents Antivirals Benzoxazines Biological and medical sciences Case-Control Studies CD4 Lymphocyte Count - statistics & numerical data Cohort Studies Dideoxynucleosides - therapeutic use Drug combinations Female Highly active antiretroviral therapy HIV HIV Infections - blood HIV Infections - drug therapy HIV Infections - transmission HIV Protease Inhibitors - therapeutic use HIV-1 - drug effects HIV-1 - enzymology HIV-1 - genetics HIV-1 - isolation & purification HIV/AIDS Human viral diseases Humans Immunology Indinavir - therapeutic use Infectious diseases Male Medical sciences Outpatients - statistics & numerical data Oxazines - therapeutic use Pharmacology. Drug treatments Prospective Studies Referents Reverse Transcriptase Inhibitors - therapeutic use RNA RNA, Viral - blood RNA, Viral - genetics RNA, Viral - metabolism Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load - statistics & numerical data Viruses
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Zusammenfassung:	To analyze factors associated with long-term (⩾2 years) suppression of virus load (VL), we performed a nested case-control analysis of 1235 Human Immunodeficiency Virus Outpatient Study cohort participants who were well characterized by multiple VL and CD4+ cell count determinations. Of these patients, 286 (23.1%) had maintained undetectable VLs (i.e.,
ISSN:	1058-4838 1537-6591
DOI:	10.1086/376992