Schultz-Dale reaction in mouse trachea

Schultz-Dale reaction in mouse trachea

A method was developed to induce contraction of immunologically sensitized mouse trachea by antigen (Schultz-Dale reaction). The response was mediated by immunoglobulin (lg) E antibody directed against either the hapten DNP, the hapten carrier conjugate DNP-keyhole limpet hemocyanin (KLH), or the un...

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Veröffentlicht in:Journal of pharmacological methods 1981-08, Vol.6 (1), p.39-43
Hauptverfasser: Koppel, Gary A., Haisch, Klaus D., Spaethe, Stephen M., Schmidtke, Jon R., Fleisch, Jerome H.
Format: Artikel
Sprache:eng
Schlagworte:
Anaphylaxis - physiopathology
Animals
Antibodies
Antigen-Antibody Reactions
Antigens
Dinitrophenols - immunology
Female
Hemocyanins - immunology
In Vitro Techniques
Mice
Mice, Inbred BALB C
Mouse
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Muscle, Smooth - immunology
Schultz-Dale
Trachea
Trachea - immunology
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Beschreibung
Zusammenfassung:A method was developed to induce contraction of immunologically sensitized mouse trachea by antigen (Schultz-Dale reaction). The response was mediated by immunoglobulin (lg) E antibody directed against either the hapten DNP, the hapten carrier conjugate DNP-keyhole limpet hemocyanin (KLH), or the unmodified carrier KLH. Tracheal contractions were elicited by DNP-KLH, KLH, or DNP-bovine serum albumin (BSA) but not by DNP or BSA alone. This procedure represents a useful index of in vitro anaphylaxis in mouse airway smooth muscle.
ISSN:0160-5402
DOI:10.1016/0160-5402(81)90082-6