Control of Liposidomycin Production through Precursor-directed Biosynthesis

Liposidomycin, a potent inhibitor of bacterial peptidoglycan biosynthesis, represents the main component of a group of over 24 closely related, fatty acyl nucleoside antibiotics produced by Streptomyces. Exogeneously supplied myristic acid or palmitic acid resulted in the almost exclusive production...

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Veröffentlicht in:	Journal of antibiotics 2003/06/25, Vol.56(6), pp.552-556
Hauptverfasser:	KAGAMI, SHINOBU, ESUMI, YASUAKI, NAKAKOSHI, MASAMICHI, YOSHIHAMA, MAKOTO, KIMURA, KEN-ICHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Fermentation Medical sciences Myristic Acid - pharmacology Palmitic Acid - pharmacology Pharmacology. Drug treatments Streptomyces Streptomyces griseus
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Beschreibung
Zusammenfassung:	Liposidomycin, a potent inhibitor of bacterial peptidoglycan biosynthesis, represents the main component of a group of over 24 closely related, fatty acyl nucleoside antibiotics produced by Streptomyces. Exogeneously supplied myristic acid or palmitic acid resulted in the almost exclusive production of liposidomycin C-(III) and/or M-(III). Exogeneously supplied [1-13C]-palmitic acid was incorporated directly into liposidomycin M-(III) as judged by the FAB-MS and 13C NMR spectra.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.56.552