Development of a phase III trial of hematopoietic stem cell transplantation for systemic lupus erythematosus

At Northwestern University, a phase I/II trial of hematopoietic stem cell transplant (HSCT) for systemic lupus erythematosus (SLE) has shown promising results. A phase III HSCT trial is being developed to confirm efficacy of HSCT vs continuing the currently accepted standard of care, intravenous pul...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2003-08, Vol.32 (S1), p.S49-S51
Hauptverfasser:	Burt, R K, Marmont, A, Arnold, R, Heipe, F, Firestein, G S, Carrier, E, Hahn, B, Barr, W, Oyama, Y, Snowden, J, Kalunian, K, Traynor, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone marrow Care and treatment Chronic conditions Clinical Protocols Clinical trials Clinical Trials, Phase III as Topic - methods Cyclophosphamide Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Humans Intravenous administration Lupus Lupus Erythematosus, Systemic - mortality Lupus Erythematosus, Systemic - therapy Patient outcomes Severity of Illness Index Stem cell transplantation Stem cells Systemic lupus erythematosus Transplantation Transplantation Conditioning - methods Transplants & implants
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Zusammenfassung:	At Northwestern University, a phase I/II trial of hematopoietic stem cell transplant (HSCT) for systemic lupus erythematosus (SLE) has shown promising results. A phase III HSCT trial is being developed to confirm efficacy of HSCT vs continuing the currently accepted standard of care, intravenous pulse cyclophosphamide.
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1703943