Phenolic Constituents from Dalbergia cochinchinensis
Three new phenolic compounds (1-3), along with five known phenolics, 4'-hydroxy-2'-methoxychalcone (4), latinone (5), dalbergiphenol (6), 7-hydroxyflavanone, and dalbergin (7), have been isolated from the stems of Dalbergia cochinchinensis. The structures of 1-3 were established by spectro...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2003-08, Vol.66 (8), p.1128-1131 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 66 |
| creator | SHIROTA, Osamu PATHAK, Vibha SEKITA, Setsuko SATAKE, Motoyoshi NAGASHIMA, Yoshio HIRAYAMA, Yutaka HAKAMATA, Yusuke HAYASHI, Tatsuo |
| description | Three new phenolic compounds (1-3), along with five known phenolics, 4'-hydroxy-2'-methoxychalcone (4), latinone (5), dalbergiphenol (6), 7-hydroxyflavanone, and dalbergin (7), have been isolated from the stems of Dalbergia cochinchinensis. The structures of 1-3 were established by spectroscopic techniques including 1D and 2D NMR methods. The inhibitory activity against testosterone 5 alpha-reductase, which causes androgen-dependent diseases, was also examined for selected compounds. |
| doi_str_mv | 10.1021/np0300683 |
| format | Article |
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The structures of 1-3 were established by spectroscopic techniques including 1D and 2D NMR methods. The inhibitory activity against testosterone 5 alpha-reductase, which causes androgen-dependent diseases, was also examined for selected compounds.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np0300683</identifier><identifier>PMID: 12932142</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>5-alpha Reductase Inhibitors ; Androgen Antagonists - chemistry ; Androgen Antagonists - isolation & purification ; Androgen Antagonists - pharmacology ; Biological and medical sciences ; Dalbergia - chemistry ; General pharmacology ; Medical sciences ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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Nat. Prod</addtitle><description>Three new phenolic compounds (1-3), along with five known phenolics, 4'-hydroxy-2'-methoxychalcone (4), latinone (5), dalbergiphenol (6), 7-hydroxyflavanone, and dalbergin (7), have been isolated from the stems of Dalbergia cochinchinensis. The structures of 1-3 were established by spectroscopic techniques including 1D and 2D NMR methods. The inhibitory activity against testosterone 5 alpha-reductase, which causes androgen-dependent diseases, was also examined for selected compounds.</description><subject>5-alpha Reductase Inhibitors</subject><subject>Androgen Antagonists - chemistry</subject><subject>Androgen Antagonists - isolation & purification</subject><subject>Androgen Antagonists - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Dalbergia - chemistry</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenols - chemistry</subject><subject>Phenols - isolation & purification</subject><subject>Phenols - pharmacology</subject><subject>Plant Stems - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Vietnam</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz81Kw0AUBeBBFFurC19AstFd9M6dzE-W0qoVihas0t0wTSZ2NJnUTAL69kZadXE5i_Nx4BJySuGSAtIrvwEGIBTbI0PKEWIByPfJEKhgMVMiGZCjEN4AepbyQzKgmDKkCQ5JMl9bX5cui8a1D61rO-vbEBVNXUUTU65s8-pMlNXZ2vmfsz64cEwOClMGe7LLEXm-vVmMp_Hs8e5-fD2LHUrexgwTJRGMTK3JjcyzvEAhEwTMhaDMykIaqVYSqaJMFTlSCkCtYFD0PuFsRC62u5um_uhsaHXlQmbL0nhbd0FLxpUUIu3h2Q52q8rmetO4yjRf-vfPHpzvgAmZKYvG-MyFf8dByRRl7-Ktc6G1n3-9ad61kExyvZg_6eULVzhdcv3AvgG_BW5u</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>SHIROTA, Osamu</creator><creator>PATHAK, Vibha</creator><creator>SEKITA, Setsuko</creator><creator>SATAKE, Motoyoshi</creator><creator>NAGASHIMA, Yoshio</creator><creator>HIRAYAMA, Yutaka</creator><creator>HAKAMATA, Yusuke</creator><creator>HAYASHI, Tatsuo</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Phenolic Constituents from Dalbergia cochinchinensis</title><author>SHIROTA, Osamu ; PATHAK, Vibha ; SEKITA, Setsuko ; SATAKE, Motoyoshi ; NAGASHIMA, Yoshio ; HIRAYAMA, Yutaka ; HAKAMATA, Yusuke ; HAYASHI, Tatsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i275t-3248720a79eada7dcdf2674202d6613e7f7a78b7218138fd211001e630fada453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>5-alpha Reductase Inhibitors</topic><topic>Androgen Antagonists - chemistry</topic><topic>Androgen Antagonists - isolation & purification</topic><topic>Androgen Antagonists - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Dalbergia - chemistry</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenols - chemistry</topic><topic>Phenols - isolation & purification</topic><topic>Phenols - pharmacology</topic><topic>Plant Stems - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Vietnam</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIROTA, Osamu</creatorcontrib><creatorcontrib>PATHAK, Vibha</creatorcontrib><creatorcontrib>SEKITA, Setsuko</creatorcontrib><creatorcontrib>SATAKE, Motoyoshi</creatorcontrib><creatorcontrib>NAGASHIMA, Yoshio</creatorcontrib><creatorcontrib>HIRAYAMA, Yutaka</creatorcontrib><creatorcontrib>HAKAMATA, Yusuke</creatorcontrib><creatorcontrib>HAYASHI, Tatsuo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIROTA, Osamu</au><au>PATHAK, Vibha</au><au>SEKITA, Setsuko</au><au>SATAKE, Motoyoshi</au><au>NAGASHIMA, Yoshio</au><au>HIRAYAMA, Yutaka</au><au>HAKAMATA, Yusuke</au><au>HAYASHI, Tatsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenolic Constituents from Dalbergia cochinchinensis</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. 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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2003-08, Vol.66 (8), p.1128-1131 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | 5-alpha Reductase Inhibitors Androgen Antagonists - chemistry Androgen Antagonists - isolation & purification Androgen Antagonists - pharmacology Biological and medical sciences Dalbergia - chemistry General pharmacology Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols - chemistry Phenols - isolation & purification Phenols - pharmacology Plant Stems - chemistry Plants, Medicinal - chemistry Vietnam |
| title | Phenolic Constituents from Dalbergia cochinchinensis |
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