Phenolic Constituents from Dalbergia cochinchinensis

Three new phenolic compounds (1-3), along with five known phenolics, 4'-hydroxy-2'-methoxychalcone (4), latinone (5), dalbergiphenol (6), 7-hydroxyflavanone, and dalbergin (7), have been isolated from the stems of Dalbergia cochinchinensis. The structures of 1-3 were established by spectro...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2003-08, Vol.66 (8), p.1128-1131
Hauptverfasser:	SHIROTA, Osamu, PATHAK, Vibha, SEKITA, Setsuko, SATAKE, Motoyoshi, NAGASHIMA, Yoshio, HIRAYAMA, Yutaka, HAKAMATA, Yusuke, HAYASHI, Tatsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	5-alpha Reductase Inhibitors Androgen Antagonists - chemistry Androgen Antagonists - isolation & purification Androgen Antagonists - pharmacology Biological and medical sciences Dalbergia - chemistry General pharmacology Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols - chemistry Phenols - isolation & purification Phenols - pharmacology Plant Stems - chemistry Plants, Medicinal - chemistry Vietnam
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Zusammenfassung:	Three new phenolic compounds (1-3), along with five known phenolics, 4'-hydroxy-2'-methoxychalcone (4), latinone (5), dalbergiphenol (6), 7-hydroxyflavanone, and dalbergin (7), have been isolated from the stems of Dalbergia cochinchinensis. The structures of 1-3 were established by spectroscopic techniques including 1D and 2D NMR methods. The inhibitory activity against testosterone 5 alpha-reductase, which causes androgen-dependent diseases, was also examined for selected compounds.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0300683