Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination

Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination

Permanent axotomy in cats produced by hind limb ablation results in sequential pathological alterations of myelinated fibers of the proximal nerve stump. The changes are like those previously described for human uremic neuropathy and such system atrophies as Friedreich's ataxia; axonal atrophy...

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Veröffentlicht in:Annals of neurology 1981-06, Vol.9 (6), p.575-583
Hauptverfasser: Dyck, Peter James, Lais, Alfred C., Karnes, Jeannine L., Sparks, Margaret, Hunder, Heidi, Low, Phillip A., Windebank, Anthony J.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Atrophy
Axons - pathology
Axons - surgery
Cats
Demyelinating Diseases - physiopathology
Disease Models, Animal
Myelin Sheath - physiology
Nerve Regeneration
Peripheral Nerves - physiopathology
Peripheral Nerves - surgery
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Zusammenfassung:Permanent axotomy in cats produced by hind limb ablation results in sequential pathological alterations of myelinated fibers of the proximal nerve stump. The changes are like those previously described for human uremic neuropathy and such system atrophies as Friedreich's ataxia; axonal atrophy → myelin wrinkling → nodal lengthening and internodal demyelination → remyelination.
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.410090611