Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia

Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potenci...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2003-08, Vol.66 (8), p.1132-1135
Hauptverfasser:	Li, X.C, Jacob, M.R, ElSohly, H.N, Nagle, D.G, Smillie, T.J, Walker, L.A, Clark, A.M
Format:	Artikel
Sprache:	eng
Schlagworte:	6-nonadecynoic acid 6-octadecynoic acid alkynes Amphotericin B - pharmacology antibacterial properties Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology antifungal properties Aspergillus fumigatus Biological and medical sciences Candida albicans Candida albicans - drug effects chemical structure Cryptococcus neoformans cytotoxicity drug resistance Drug Resistance, Microbial Fatty Acids, Monounsaturated - chemistry Fatty Acids, Monounsaturated - isolation & purification Fatty Acids, Monounsaturated - pharmacology fluconazole Fluconazole - pharmacology Gas Chromatography-Mass Spectrometry General pharmacology Medical sciences Methylation Microbial Sensitivity Tests Molecular Structure Mycobacterium intracellulare Pentagonia gigantifolia Peru Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant extracts Plant Roots - chemistry roots Rubiaceae spectral analysis Sphingolipids Staphylococcus aureus unsaturated fatty acids
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Zusammenfassung:	Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 against C. albicans.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np030196r