Interleukin-1B polymorphism is associated with age at onset of Alzheimer’s disease
Interleukin-1α (IL-1α) and IL-1β are two pro-inflammatory cytokines involved in the pathogenesis of Alzheimer’s disease (AD). The genes coding for IL-1α ( IL-1A) and for IL-1β ( IL-1B) are clustered in chromosome 2q14–2q14.2. In a previous work, we investigated the role of IL-1A promoter polymorphis...
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Veröffentlicht in: | Neurobiology of aging 2003-11, Vol.24 (7), p.927-931 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Interleukin-1α (IL-1α) and IL-1β are two pro-inflammatory cytokines involved in the pathogenesis of Alzheimer’s disease (AD). The genes coding for IL-1α (
IL-1A) and for IL-1β (
IL-1B) are clustered in chromosome 2q14–2q14.2. In a previous work, we investigated the role of
IL-1A promoter polymorphism (−889 position) in AD pathogenesis:
IL-1A −889 TT genotype was associated with sporadic early onset AD. We now report the study on polymorphism of exon 5
IL-1B in position +3953, the nearest polymorphism to −889
IL-1A. We found that the genotype distribution of
IL-1B +3953 varied significantly between patients with early and late onset of AD (
P |
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ISSN: | 0197-4580 1558-1497 |
DOI: | 10.1016/S0197-4580(03)00011-3 |